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DBCO-PEG (Dibenzocyclooctyne-Polyethylene Glycol) is a versatile compound used in chemical biology and materials science. It combines a dibenzocyclooctyne (DBCO) group with a polyethylene glycol (PEG) chain, making it ideal for bioorthogonal click chemistry. This compound enables efficient, catalyst-free reactions for precise biomolecule labeling, drug delivery, and surface modification, while its PEG component enhances solubility and biocompatibility.

Cat# Name Structure M.W. Purity Pricing
Active-Mono-Sulfone-PEG-DBCO
AP13200Active-Mono-Sulfone-PEG9-DBCO1070.3≥98% Pricing
Biotin DBCO PEG
AP10321DBCO-NH-PEG2-Biotin661.81≥95% Pricing
AP10322DBCO-NH-PEG4-Biotin749.92≥95% Pricing
AP10323DBCO-NH-PEG6-Biotin838.02≥95% Pricing
AP11070Dde Biotin-PEG4-DBCO872.09≥95% Pricing
AP13177Biotin-PEG8-DBCO 926.1≥98% Pricing
AP11067Diazo Biotin-PEG3-DBCO973.16≥95% Pricing
AP10324DBCO-NH-PEG12-Biotin1102.34≥95% Pricing
Boc-HyNic-PEG-Amino-DBCO
AP10609Boc-HyNic-PEG2-Amino-DBCO670.76≥95% Pricing
DBCO TFP Ester
AP12698Sulfo DBCO-TFP Ester604.53≥95% Pricing
AP12699DBCO-PEG5-TFP Ester744.74≥95% Pricing
AP13165Sulfo DBCO-PEG4-TFP ester851.8≥95% Pricing
DBCO-acid & DBCO-PEG acid
AP10025DBCO-acid305.33≥98% Pricing
AP10753DBCO-C5 acid319.35≥95% Pricing
AP10026DBCO-acid C6333.38≥98% Pricing
AP10299DBCO-NH-C4-acid404.46≥95% Pricing
AP11108DBCO-PEG1-acid420.47≥95% Pricing
AP10308DBCO-NH-PEG2-acid464.51≥95% Pricing
AP14196DBCO-S-S-acid468.60≥95% Pricing
AP10029DBCO-PEG3-CH2CO2H494.54≥98% Pricing
AP10309DBCO-NH-PEG3-acid508.56≥95% Pricing
AP11109DBCO-PEG4-acid552.62≥95% Pricing
AP10310DBCO-NH-PEG5-acid596.67≥95% Pricing
AP13159DBCO-PEG6-acid640.7≥95% Pricing
AP13161Sulfo DBCO-PEG3-acid659.7≥95% Pricing
AP10311DBCO-NH-PEG7-acid684.77≥95% Pricing
AP11110DBCO-PEG8-acid728.84≥95% Pricing
AP11111DBCO-PEG12-acid905.05≥95% Pricing
AP10312DBCO-NH-PEG12-acid949.09≥95% Pricing
AP13160DBCO-PEG24-acid1433.7≥95% Pricing
DBCO-Alcohol & DBCO-PEG-Alcohol
AP11120DBCO-C2-alcohol348.4≥95% Pricing
AP11121DBCO-C3-alcohol362.43≥95% Pricing
AP10756DBCO-PEG4-alcohol508.61≥95% Pricing
DBCO-amine & DBCO-PEG-amine
AP10297DBCO-amine276.33≥95% Pricing
AP13169DBCO-amine TFA salt390.4≥95% Pricing
AP11123DBCO-PEG1-amine391.47≥95% Pricing
AP10298DBCO-C4-amine TFA salt404.38≥95% Pricing
AP11122Sulfo DBCO-amine427.48≥95% Pricing
AP10304DBCO-NH-PEG2-amine435.52≥95% Pricing
AP10755DBCO-C4-PEG2-amine435.52≥95% Pricing
AP10305DBCO-NH-PEG4-amine523.62≥95% Pricing
AP11124DBCO-PEG4-amine523.63≥95% Pricing
AP11128DBCO-C2-PEG4-amine595.69≥95% Pricing
AP11129DBCO-C3-PEG4-amine609.72≥95% Pricing
AP10306DBCO-NH-PEG6-amine611.73≥95% Pricing
AP11125DBCO-PEG6-amine611.74≥95% Pricing
AP11127Sulfo DBCO-PEG4-amine674.77≥95% Pricing
AP13170DBCO-PEG8-amine TFA salt699.8≥95% Pricing
AP11126DBCO-PEG9-amine743.9≥95% Pricing
AP10307DBCO-NH-PEG12-amine876.04≥95% Pricing
AP13173DBCO-PEG23-amine1360.7≥98% Pricing
AP13172DBCO-PEG24-amine TFA salt1404.7≥95% Pricing
DBCO-Biotin & DBCO-PEG-Biotin
AP10303DBCO-Biotin502.63≥95% Pricing
AP11066DBCO-Sulfo-Link-biotin653.77≥95% Pricing
AP10321DBCO-NH-PEG2-Biotin661.81≥95% Pricing
AP12585Desthiobiotin-PEG4-DBCO719.87≥95% Pricing
AP11069DBCO-PEG4-Desthiobiotin719.88≥95% Pricing
AP10322DBCO-NH-PEG4-Biotin749.92≥95% Pricing
AP10323DBCO-NH-PEG6-Biotin838.02≥95% Pricing
AP13177Biotin-PEG8-DBCO 926.1≥98% Pricing
AP10324DBCO-NH-PEG12-Biotin1102.34≥95% Pricing
DBCO-Maleimide & DBCO-PEG-Maleimide
AP10860DBCO-Maleimide356.37≥95% Pricing
AP10300DBCO-Mal427.45≥95% Pricing
AP10855DBCO-Sulfo-Maleimide578.60≥95% Pricing
AP10313DBCO-NH-PEG2-Mal586.64≥95% Pricing
AP10859DBCO-amido-PEG4-Maleimide603.66≥95% Pricing
AP13841DBCO-PEG4-Maleimide674.74≥95% Pricing
AP10858DBCO-amido-PEG4-amido-Maleimide674.74≥95% Pricing
AP10315DBCO-NH-PEG6-Mal762.85≥95% Pricing
AP12611Sulfo DBCO-PEG4-Maleimide825.89≥95% Pricing
AP10856DBCO-Sulfo-PEG4-Maleimide825.89≥95% Pricing
AP13183DBCO-PEG8-Maleimide851≥95% Pricing
AP10316DBCO-NH-PEG12-Maleimide1027.16≥95% Pricing
AP13184DBCO-PEG24-Maleimide1555.8≥95% Pricing
DBCO-mPEG
AP13194m-PEG2-DBCO406.5≥95% Pricing
AP11148m-PEG4-DBCO494.59≥95% Pricing
AP13195m-PEG6-DBCO582.7≥95% Pricing
AP11149m-PEG8-DBCO670.8≥95% Pricing
AP11150m-PEG12-DBCO847.01≥95% Pricing
AP13196m-PEG24-DBCO1375.7≥95% Pricing
DBCO-NHCO-PEG-t-butyl ester
AP13158DBCO-NHCO-PEG4-t-butyl ester608.7≥98% Pricing
DBCO-NHS ester
AP10863DBCO-NHS ester402.40≥95% Pricing
AP10862DBCO-C6-NHS ester430.45≥95% Pricing
AP10864DBCO-C4-SulfoNHS ester482.46≥95% Pricing
AP13157DBCO-C2-SulfoNHS ester482.46≥98% Pricing
AP10301DBCO-COONHS Ester501.53≥95% Pricing
AP10865DBCO-C6-SulfoNHS ester510.52≥95% Pricing
AP13156DBCO-Sulfo-NHS Ester532.50≥95% Pricing
AP12701PC DBCO-NHS Ester945.98≥95% Pricing
DBCO-PEG-DBCO
AP13178DBCO-PEG2-DBCO722.8≥98% Pricing
AP11138DBCO-PEG4-DBCO810.95≥95% Pricing
AP11139DBCO-PEG5-DBCO855≥95% Pricing
AP13179DBCO-PEG6-DBCO 899.1≥98% Pricing
AP13180DBCO-PEG8-DBCO987.2≥98% Pricing
AP11140DBCO-PEG9-DBCO1031.21≥95% Pricing
AP11141DBCO-PEG10-DBCO1075.27≥95% Pricing
AP13181DBCO-PEG12-DBCO1163.4≥98% Pricing
AP11142DBCO-PEG13-DBCO1207.43≥95% Pricing
AP13182DBCO-PEG24-DBCO1433.68≥95% Pricing
DBCO-PEG-NH-Boc
AP11134DBCO-NH-Boc376.46≥95% Pricing
AP11130DBCO-PEG1-NH-Boc491.59≥95% Pricing
AP11131DBCO-PEG2-NH-Boc535.64≥95% Pricing
AP10678DBCO-NH-PEG4-NH-Boc623.74≥95% Pricing
AP11132DBCO-PEG4-NH-Boc623.75≥95% Pricing
AP11135DBCO-C2-PEG4-NH-Boc695.81≥95% Pricing
AP11136DBCO-C3-PEG4-NH-Boc709.84≥95% Pricing
AP13174DBCO-PEG6-NH-Boc 711.9≥98% Pricing
AP13202DBCO-PEG8-NH-Boc 800≥98% Pricing
AP11133DBCO-PEG9-NH-Boc844.01≥95% Pricing
AP13203DBCO-PEG12-NH-Boc976.2≥95% Pricing
AP13175DBCO-PEG23-NH-Boc1460.8≥98% Pricing
DBCO-PEG-NHS ester
AP11112DBCO-PEG1-NHS ester517.54≥95% Pricing
AP10317DBCO-NH-PEG2-NHS ester561.58≥95% Pricing
AP10030DBCO-PEG3-CH2CO-NHS ester591.61≥98% Pricing
AP11113DBCO-PEG4-NHS ester649.7≥95% Pricing
AP11117DBCO-NH-PEG4-NHS ester649.7≥95% Pricing
AP10318DBCO-NH-PEG5-NHS ester693.74≥95% Pricing
AP11114DBCO-PEG5-NHS ester693.75≥95% Pricing
AP13162DBCO-PEG6-NHS ester737.8≥95% Pricing
AP13164Sulfo DBCO-PEG3-NHS ester756.8≥95% Pricing
AP10319DBCO-NH-PEG7-NHS ester781.85≥95% Pricing
AP11115DBCO-PEG8-NHS ester825.91≥95% Pricing
AP11116DBCO-PEG12-NHS ester1002.12≥95% Pricing
AP10320DBCO-NH-PEG13-NHS ester1046.16≥95% Pricing
AP13163DBCO-PEG24-NHS ester1530.8≥95% Pricing
DBCO-PEG-peptide
AP13849DBCO-Gly-Gly-Gly598.63≥95% Pricing
AP11144Gly-Gly-Gly-PEG4-DBCO694.79≥95% Pricing
AP14192DBCO-PEG4-Val-Ala-PAB828.00≥95% Pricing
AP14191DBCO-PEG4-MMAF1266.60≥95% Pricing
AP13199DBCO-PEG4-Val-Cit-PAB-PNP1079.2≥98% Pricing
DBCO-PEG-PFP ester
AP11118DBCO-PEG2-PFP ester630.57≥95% Pricing
AP11119DBCO-PEG4-PFP ester718.67≥95% Pricing
AP13166DBCO-PEG8-PFP ester894.9≥95% Pricing
DBCO-PEG-silane
AP11143DBCO-PEG4-triethoxysilane755.98≥95% Pricing
DBCO-PEG-triethoxysilane
AP13083DBCO-trimethoxysilane466.61≥95% Pricing
AP13085DBCO-C6-trimethoxysilane494.66≥95% Pricing
AP13084DBCO-triethoxysilane508.69≥95% Pricing
AP13086DBCO-C6-triethoxysilane536.74≥95% Pricing
AP11143DBCO-PEG4-triethoxysilane755.98≥95% Pricing
Diketone-PEG-DBCO
AP11312Diketone-PEG12-DBCO1092.29≥95% Pricing
DNP-PEG-DBCO
AP12236DNP-PEG4-DBCO689.72≥95% Pricing
DOTA-PEG-DBCO
AP11147DOTA-PEG5-C6-DBCO982.14≥95% Pricing
DSPE-PEG-DBCO
AP10165DSPE-PEG4-DBCO1282.67≥95% Pricing
Fluorescein-DBCO
AP11137Fluorescein-DBCO665.72≥95% Pricing
Hydroxy-PEG-DBCO
AP13167Hydroxy-PEG3-DBCO480.6≥98% Pricing
AP13842Hydroxy-PEG4-DBCO508.61≥95% Pricing
AP13168Hydroxy-PEG7-DBCO 656.8≥98% Pricing
HyNic-PEG-Amino-DBCO
AP10603HyNic-PEG2-Amino-DBCO610.70≥95% Pricing
AP15265HyNic-PEG4-Amino-DBCO698.81≥95% Pricing
Lipid-PEG-DBCO
AP10700Oleic-DBCO540.78≥95% Pricing
Methyltetrazine-PEG-DBCO
AP13188Methyltetrazine-PEG2-DBCO562.6≥95% Pricing
AP13189Methyltetrazine-PEG4-DBCO650.7≥98% Pricing
AP11146Methyltetrazine-DBCO683.74≥95% Pricing
AP13190Methyltetrazine-PEG6-DBCO 738.8≥97% Pricing
AP13191Methyltetrazine-PEG8-DBCO827≥95% Pricing
AP11145Methyltetrazine-PEG12-DBCO1003.16≥95% Pricing
AP13192Methyltetrazine-PEG24-DBCO1531.8≥95% Pricing
Other-DBCO-PEG
AP12950DBCO-propanamide-thiol364.463≥ (95%) Pricing
AP10758DBCO-C5-NHS ester416.43≥95% Pricing
AP10757DBCO-C4-PEG3-amine479.57≥95% Pricing
AP10302DBCO-CONH-S-S-COONHS Ester565.66≥95% Pricing
AP12697DBCO-STP Ester583.49≥95% Pricing
AP10686DBCO-Amine-PEG3-Fmoc701.81≥95% Pricing
AP10747DBCO-PEG4 acetic-EVCit-PAB1041.20≥95% Pricing
AP10748DBCO-PEG4-propionic EVCit-PAB1055.24≥95% Pricing
PEG-DBCO-PEG
AP11746N-DBCO-N-bis(PEG2-acid)624.69≥95% Pricing
AP11749N-DBCO-N-bis(PEG2-NHS ester)818.83≥95% Pricing
TAMRA-PEG-DBCO
AP10710TAMRA-PEG4-DBCO936.06≥95% Pricing
TCO-PEG-DBCO
AP11027TCO-PEG1-amido-DBCO543.65≥95% Pricing
AP10842TCO-PEG2-DBCO587.71≥95% Pricing
AP10843TCO-PEG3-DBCO631.76≥95% Pricing
AP11028TCO-PEG4-DBCO675.8≥95% Pricing
AP10845TCO-PEG5-DBCO719.86≥95% Pricing
AP13185TCO-PEG6-DBCO763.9≥95% Pricing
AP13186TCO-PEG8-DBCO852≥95% Pricing
AP10742TCO-PEG12-DBCO1028.23≥95% Pricing
AP13187TCO-PEG24-DBCO1556.9≥95% Pricing

Bulk Inquiry


    DBCO-PEG (Dibenzocyclooctyne-Polyethylene Glycol) is a versatile compound in the field of chemical biology and materials science, known for its use in bioorthogonal click chemistry. This compound combines a dibenzocyclooctyne (DBCO) group with a polyethylene glycol (PEG) chain, offering unique properties for conjugation and surface modification.

    Advantages

    • High Efficiency: The DBCO-azide reaction is highly efficient and does not require catalysts, making it a straightforward choice for many applications.
    • Bioorthogonal Nature: The reaction is bioorthogonal, allowing for precise conjugation in living systems without interfering with native biological functions.
    • Enhanced Solubility: The PEG component significantly increases the solubility of the compound, facilitating its use in aqueous environments.liposome-antibody DBCO-Azide Conjugate

    Applications

    1. Bioorthogonal Click Chemistry
      • Site-Specific Labeling: DBCO-PEG is used to attach various labels or probes (e.g., fluorescent dyes, drugs) to azide-functionalized biomolecules. This enables precise and site-specific labeling, which is crucial for studying biomolecular interactions and cellular processes.
      • Drug Delivery: In drug delivery systems, DBCO-PEG can be used to attach therapeutic agents to targeting molecules or carriers, enhancing specificity and reducing off-target effects.
    2. Biomedical Research
      • Imaging: DBCO-PEG is utilized in imaging applications, where it helps in tagging biological molecules or cells with imaging agents. This aids in tracking and visualizing cellular processes in vivo and in vitro.
      • Diagnostics: Used in diagnostic assays and sensors where precise and stable conjugation is required for accurate detection and measurement.
    3. Material Science
      • Surface Modification: DBCO-PEG can be used to functionalize surfaces of materials such as nanoparticles or substrates. The PEG chain improves solubility and biocompatibility, while the DBCO group allows for further functionalization with azide-containing compounds.
      • Polymer Chemistry: Incorporated into polymers to create custom materials with specific properties, such as enhanced solubility or tailored reactivity.
    4. Chemical Biology
      • Protein Engineering: Enables the attachment of functional groups to proteins for studies on protein structure and function. DBCO-PEG helps in creating stable and well-defined protein conjugates.
    Ref: Pang Y, Liu J, Qi Y, Li X, Chilkoti A. A Modular Method for the High-Yield Synthesis of Site-Specific Protein-Polymer Therapeutics. Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10296-300.  Introduction: Click Chemistry Neal K. Devaraj and M. G. Finn Chemical Reviews 2021 121 (12), 6697-6698.