The Orbitrap is an ion trap mass analyzer. It consists of two outer electrodes and a central electrode, which enable it to act as both an analyzer and detector. Ions entering the Orbitrap are captured through “electrodynamic squeezing,” after which they oscillate around the central electrode and in between the two outer electrodes. Different ions oscillate at different frequencies, resulting in their separation. By measuring the oscillation frequencies induced by ions on the outer electrodes, the mass spectra of the ions are acquired using image current detection. The Orbitrap mass analyzer is a Fourier Transform mass analyzer analog of FT-ion cyclotron resonance (ICR) technology and it has a much smaller instrument size and is easier to operate.

Key benefits of Orbitrap mass spectrometry

Unparalleled sensitivity, resolution, and accuracy

Orbitrap technology drives high-resolution, accurate-mass (HRAM) data with incredibly high resolution of up to 500,000 FWHM at m/z 200. The superior resolving capabilities of Orbitrap technology provides accurate mass assignment of injected analytes with sub-1-ppm mass accuracy. Orbitrap mass spectrometers provides researchers with unprecedented qualitative/quantitative analysis tools with high selectivity and sensitivity.

Because Orbitrap technology provides quantitative and qualitative HRAM analytical capability in a single platform and often in a single run, it has been increasingly applied towards a range of challenging applications requiring high selectivity and sensitivity.

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When the instrument generates full-scan HRAM data during untargeted analysis, easy identification of novel compounds and retrospective data analysis are accomplished without the need to re-run samples. During targeted analysis scans, the instrument confidently achieves confirmation and identification of residual small and large molecules.

At AxisPharm, our clients have the options of choosing from a full range of Orbitrap instruments such as Orbitrap Discovery, Q-Exactive and Orbitrap Fusion Lumos.