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The tetrazine ligation is the reaction of a trans-cyclooctene and an s-tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-Diels Alder reaction to eliminate nitrogen gas. This is a fast reaction with a second order rate constant of 2000 M-1-S-1 (in 9:1 methanol/water) allowing modification of biomolecules at very low concentrations. This ligation can be performed in aqueous media with very fast speed. Reactions have also been performed using TCO or norbornenes as dienophiles at second order rates on the order of 1 M-1-S-1 in aqueous media. The reaction has been applied in labeling live cells and other bio-entities.

TCO-PEG
  • Other-TCO-PEG
  • TCO-OH & TCO-PEG-OH
  • TCO-PEG-Acid
  • TCO-PEG-Amine
  • TCO-PEG-biotin
  • TCO-PEG-DBCO
  • TCO-PEG-Maleimide
  • TCO-PEG-NHS ester
  • TCO-PEG-oxyamine
  • TCO-PEG-peptide
  • TCO-PEG-PNB
  • TCO-PEG-TCO
  • TCO-PEG-TFP ester
  • TCO-PEG-triethoxysilane
Catalog# Name Structure M.W. Purity Pricing
Other-TCO-PEG
AP10598TCO-PEG1-Br233.15≥95% Pricing
AP11029TCO-PEG5-BCN608.76≥95% Pricing
AP10039TCO PEG3 CH2CO2H359.41≥98% Pricing
AP10040TCO PEG3 CH2CONHS456.49≥98% Pricing
AP10601TCO-NHS Acetate281.31≥95% Pricing
AP10602TCO-PEG1-Tosyl (axial)324.44≥95% Pricing
AP10002TCO-PNP291.3≥95% Pricing
TCO-OH & TCO-PEG-OH
AP10001TCO-OH126.2≥95% Pricing
AP10033TCO-OH (equatorial)126.2≥98% Pricing
AP10034TCO-OH (axial)126.2≥98% Pricing
AP10046TCO-PEG1-OH170.25≥95% Pricing
AP10597TCO-PEG1-OH (axial)170.25≥95% Pricing
AP10679TCO-PEG1-OH (equatorial)170.25≥95% Pricing
TCO-PEG-Acid
AP10600TCO-Acetic acid184.24≥95% Pricing
AP10808TCO-PEG1-acid285.34≥95% Pricing
AP10809TCO-PEG2-acid329.39≥95% Pricing
AP10810TCO-PEG3-acid373.45≥95% Pricing
AP10100TCO-PEG4-CH2 acid403.47≥95% Pricing
AP10851TCO-carbonylamino-benzamido-PEG1 acid404.46≥95% Pricing
AP10811TCO-PEG4-acid417.5≥95% Pricing
AP10852TCO-carbonylamino-benzamido-PEG2 acid448.51≥95% Pricing
AP10098TCO-PEG5 acid461.55≥95% Pricing
AP10853TCO-carbonylamino-benzamido-PEG3 acid492.56≥95% Pricing
AP10813TCO-PEG6-acid505.61≥95% Pricing
AP10854TCO-carbonylamino-benzamido-PEG4 acid536.61≥95% Pricing