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TCO PEG Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.

The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.

Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.
AxisPharm has large production capacity for high quality TCO PEG reagents with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of PEG linkers modified folate, biotin and fluorescent dye for biological applications.

TCO PEG
  • Bis-TCO PEG
  • Diazo-PEG-TCO
  • HyNic-PEG-TCO
  • N-Methylaniline-PEG-TCO
  • Other-TCO-PEG
  • SPDP-PEG-TCO
  • TCO-OH & TCO-PEG-OH
  • TCO-PEG-Acid
  • TCO-PEG-Amine
  • TCO-PEG-DBCO
  • TCO-PEG-Maleimide
  • TCO-PEG-NHS ester
  • TCO-PEG-PNB
  • TCO-PEG-TCO
  • TCO-PEG-TFP ester
  • TCO-PEG-alcohol
  • TCO-PEG-ald
  • TCO-PEG-biotin
  • TCO-PEG-oxyamine
  • TCO-PEG-peptide
  • TCO-PEG-silane
  • TCO-PEG-triethoxysilane
Cat# Name Structure M.W. Purity Pricing
Bis-TCO PEG
AP10840Bis-TCO-PEG2452.59≥95% Pricing
AP10841Bis-TCO-PEG5584.74≥95% Pricing
Diazo-PEG-TCO
AP13225Diazo-PEG3-TCO 794≥98% Pricing
HyNic-PEG-TCO
AP10599HyNic-PEG2-TCO475.59≥95% Pricing
AP10608HyNic-PEG3-TCO535.64≥95% Pricing
N-Methylaniline-PEG-TCO
AP13227N-Methylaniline-PEG3-TCO519.7≥98% Pricing
Other-TCO-PEG
AP13226m-PEG4-TCO359.5≥98% Pricing
AP10598TCO-PEG1-Br233.15≥95% Pricing
AP13060TCO-tBu ester254.37≥95% Pricing
AP10601TCO-NHS Acetate281.30≥95% Pricing
AP10002TCO-PNP291.3≥95% Pricing
AP10602TCO-PEG1-Tosyl (axial)324.44≥95% Pricing
AP10039TCO PEG3 CH2CO2H359.42≥98% Pricing
AP10141Aminooxy-PEG2-TCO HCl Salt in solution373.45≥95% Pricing
AP10040TCO PEG3 CH2CONHS456.49≥98% Pricing
AP10142Bocaminooxy-PEG2-TCO473.57≥95% Pricing
AP10892TCO-PEG1-Val-Cit-OH541.65≥95% Pricing
AP11029TCO-PEG5-BCN608.76≥95% Pricing
AP10893TCO-PEG1-Val-Cit-PAB-OH646.79≥95% Pricing
AP12630APDye 488 TCO770.82≥95% Pricing
AP10894TCO-PEG1-Val-Cit-PAB-PNP811.89≥95% Pricing
AP12631APDye 568 TCO 931.09≥95% Pricing
AP12578Cy5-TCO959.2≥95% Pricing
AP11757N-(Mal-PEG6)-N-bis(PEG7-TCO)1652.97≥95% Pricing
AP13224Bromoacetamido-PEG3-TCO493.4≥96% Pricing

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