DBCO-NH-PEG2-acid CAS:2666999-45-5 contains a Dibenzocyclooctyne (DBCO) functional group, an amino group (-NH2), and a carboxylic acid group (-COOH) attached to a PEG chain. This compound is a pivotal player in the realm of DBCO click chemistry, known for its specific and rapid reaction with azide groups in a copper-free environment.
DBCO-NH-PEG2-acid has been utilized in the development of drug delivery systems, such as polymer-drug conjugates, liposomes, and nanoparticles. The DBCO functional group reacts specifically and rapidly with azide groups through a copper-free click reaction, allowing for the facile conjugation of drug molecules or targeting moieties to the PEG chain. This enables the delivery of drugs to specific cells or tissues, enhancing the therapeutic efficacy while minimizing toxicity to healthy tissues.
DBCO-NH-PEG2-acid has been used in the development of imaging agents for biomedical applications. The DBCO functional group can be conjugated to fluorescent dyes or radioisotopes to generate imaging probes that can be used to detect and monitor diseases, such as cancer and inflammation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.