Polysarcosine

Polysarcosine (pSar), a peptide-like peptide based on the endogenous amino acid sarcosine (N-methylated glycine), has previously shown powerful stealth properties. pSar combines the excellent water solubility, protein resistance, low cytotoxicity and non-immunogenicity characteristics of PEG polymers, while being based on endogenous material. Polysarcosine can be used to generate lipids to form lipid nanoparticles (LNPs) for therapeutic applications of messenger RNA.