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Cleavable PEG Reagents play a crucial role in the success of antibody-drug conjugates. It determines the fate of the cytotoxic drug in the biological system. In order to make the ADC effective, it requires the Cleavable reagents to be stable enough in the blood circulation for a substantial amount of time to avoid side toxicity and to allow ADC to reach the target. It also requires the reagents to be labile so that they efficiently release corresponding payload in the tumor environment.

AxisPharm provides functionalized cleavable PEGs with disulfide bonds or photocleavable bonds. Different kinds of antibody-drug conjugates Reagents may be available by custom synthesis.

Cleavable Linkers
  • -S-S- Cleavable
  • Cleavable Peptide
  • Dde Cleavable Linkers
  • Disulfide Biotin
  • PC Cleavable
  • Photocleavable Biotin
  • diazo biotin probes
  • β-Glucuronide Linkers
Cat# Name Structure M.W. Purity Pricing
-S-S- Cleavable
AP11154Aminoethyl-SS-ethylamine152.27≥95% Pricing
AP11151Aminoethyl-SS-ethylalcohol153.26≥95% Pricing
AP11158Azidoethyl-SS-ethylamine178.27≥95% Pricing
AP11005Azidoethyl-SS-ethylalcohol179.26≥95% Pricing
AP11152Aminoethyl-SS-propionic acid181.27≥95% Pricing
AP11162Propargyl-PEG1-SS-alcohol192.29≥95% Pricing
AP11159Azidoethyl-SS-ethylazide204.27≥95% Pricing
AP11156Azidoethyl-SS-propionic acid207.27≥95% Pricing
AP11165Propargyl-PEG1-SS-PEG1-propargyl230.34≥95% Pricing
AP11178THP-SS-alcohol238.36≥95% Pricing
AP11155t-Boc-Cystamine252.39≥95% Pricing
AP11163Propargyl-PEG1-SS-PEG1-acid264.35≥95% Pricing
AP11172Boc-aminooxy-ethyl-SS-propanol269.37≥95% Pricing
AP11171Boc-NH-ethyl-SS-propionic acid281.39≥95% Pricing
AP11001Azido-SS-PEG2-acid295.37≥95% Pricing
AP11157Azidoethyl-SS-propionic NHS ester304.34≥95% Pricing
AP111812-hydroxyethyl disulfide mono-Tosylate308.43≥95% Pricing
AP11166Propargyl-PEG1-SS-PEG1-t-butyl ester320.46≥95% Pricing
AP11175Mal-NH-ethyl-SS-propionic acid332.39≥95% Pricing
AP11161Azidoethyl-PEG2-t-Butyl ester351.48≥95% Pricing
AP11179THP-SS-PEG1-t-butyl ester366.53≥95% Pricing
AP11167Acid-PEG2-SS-PEG2-acid386.47≥95% Pricing
AP11180THP-SS-PEG1-Tos392.54≥95% Pricing
AP11173Fmoc-NH-ethyl-SS-propionic acid403.51≥95% Pricing
AP11176Hydroxy-PEG3-SS-PEG3-alcohol418.56≥95% Pricing

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