AxisPharm provides multi functionalized DOTA PEG linkers with high purity. Provides custom synthesis of DOTA PEG reagents.
DOTA antibody conjugates have wide application in tissue imaging and tumor diagnostics. DOTA can be conjugated to monoclonal antibodies by attachment of one of the four carboxyl groups as an amide. The remaining three carboxylate anions are available for binding to the yttrium ion. The modified antibody accumulates in the tumour cells, concentrating the effects of the radioactivity of 90Y.
