DBCO-PEG24-acid contains a DBCO (dibenzocyclooctyne) functional group, an acid group (-COOH), and a PEG chain with 24 repeating units.
DBCO-PEG24-acid is a popular building block for DBCO derivatization. The acid group can react with amine to form amide bond under coupling conditons in the presence of activators such as EDC, DCC and HATU. DBCO. On the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-PEG24-acid has been extensively utilized in the development of novel drug delivery systems, such as conjugates and nanoparticles. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via click chemistry, which is a highly efficient and selective reaction.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.