Ionizable Lipids: Key to Advanced Drug Delivery

What Are Ionizable Lipids?

Ionizable lipids are crucial components in modern drug delivery systems, especially for lipid nanoparticles (LNPs) used in mRNA and gene therapies. These lipids change charge based on pH, enhancing the delivery and release of therapeutic agents inside cells.

Benefits of Ionizable Lipids

• Efficient Drug Delivery: Enhance the stability and release of drugs, including mRNA and DNA, within target cells.
• pH-Responsive Release: Release therapeutic agents in specific environments, such as acidic endosomes, for precise delivery.
• Improved Cellular Uptake: Facilitate endosomal escape, improving gene delivery and expression.
• Versatility: Customizable for various therapeutic applications, from vaccines to gene editing.

Applications

• mRNA Vaccines: Essential for delivering mRNA vaccines, such as COVID-19 vaccines, by protecting mRNA and ensuring its release inside cells.
• Gene Therapy: Used to deliver therapeutic genes and gene-editing tools like CRISPR/Cas9.
• RNA Therapeutics: Enables the effective delivery of RNA-based therapies like siRNAs and ASOs.

Why Choose AxisPharm?

• Custom Synthesis: Tailored ionizable lipids to fit your research needs.
• Expert Formulation: Advanced technology for optimal lipid nanoparticle formulation.
• Comprehensive Support: Full support from design to scale-up for your projects.

Ref:

Kairuz, D.; Samudh, N.; Ely, A.; Arbuthnot, P.; Bloom, K. Production, Characterization, and Assessment of Permanently Cationic and Ionizable Lipid Nanoparticles for Use in the Delivery of Self-Amplifying RNA Vaccines. Pharmaceutics 2023, 15, 1173.