Disulfide-biotin is a type of small molecule linker that is commonly used in bioconjugation applications. It is composed of a disulfide bond, which can be used to link proteins or other biomolecules, and a biotin group, which can be used to target the conjugate to specific receptors or binding partners.
Disulfide-biotin linkers are often used in the production of antibody-drug conjugates (ADCs), which are a type of targeted therapy that uses antibodies to deliver drugs directly to cancer cells. In this application, the disulfide bond is used to link the antibody to the drug, while the biotin group can be used to target the conjugate to specific receptors on the surface of cancer cells.
Disulfide-biotin linkers are also commonly used in the production of biosensors and other diagnostic tools, where the biotin group can be used to bind to specific molecules of interest, and the disulfide bond can be used to link the sensor or probe to other molecules or surfaces.