-S-S- Cleavable

-S-S- Cleavable refers to a type of chemical linker that is commonly used in the development of small molecule drugs and drug conjugates. The -S-S- bond is a disulfide bond that can be cleaved under certain conditions, such as exposure to reducing agents or changes in pH, leading to the release of the drug or payload.

-S-S- Cleavable linkers are often used in the development of antibody-drug conjugates (ADCs), which are a type of targeted therapy that combines the specificity of an antibody with the potency of a small molecule drug. In an ADC, the small molecule drug is conjugated to the antibody via a -S-S- Cleavable linker, which allows for the selective release of the drug in the vicinity of the target cells.

-S-S- Cleavable linkers can also be used in the development of other types of targeted therapies, such as aptamer-drug conjugates and peptide-drug conjugates. The ability to selectively release the drug in response to specific conditions makes -S-S- Cleavable linkers an attractive option for the development of targeted therapies that can improve the efficacy and reduce the toxicity of traditional small molecule drugs.