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-S-S- Cleavable refers to a type of chemical linker that is commonly used in the development of small molecule drugs and drug conjugates. The -S-S- bond is a disulfide bond that can be cleaved under certain conditions, such as exposure to reducing agents or changes in pH, leading to the release of the drug or payload.

-S-S- Cleavable linkers are often used in the development of antibody-drug conjugates (ADCs), which are a type of targeted therapy that combines the specificity of an antibody with the potency of a small molecule drug. In an ADC, the small molecule drug is conjugated to the antibody via a -S-S- Cleavable linker, which allows for the selective release of the drug in the vicinity of the target cells.

-S-S- Cleavable linkers can also be used in the development of other types of targeted therapies, such as aptamer-drug conjugates and peptide-drug conjugates. The ability to selectively release the drug in response to specific conditions makes -S-S- Cleavable linkers an attractive option for the development of targeted therapies that can improve the efficacy and reduce the toxicity of traditional small molecule drugs.

-S-S- Cleavable

Cat# Name Structure M.W. Purity Pricing
AP11154Aminoethyl-SS-ethylamine152.27≥95% Pricing
AP11151Aminoethyl-SS-ethylalcohol153.26≥95% Pricing
AP11158Azidoethyl-SS-ethylamine178.27≥95% Pricing
AP11005Azidoethyl-SS-ethylalcohol179.26≥95% Pricing
AP11152Aminoethyl-SS-propionic acid181.27≥95% Pricing
AP11162Propargyl-PEG1-SS-alcohol192.29≥95% Pricing
AP11159Azidoethyl-SS-ethylazide204.27≥95% Pricing
AP11156Azidoethyl-SS-propionic acid207.27≥95% Pricing
AP11165Propargyl-PEG1-SS-PEG1-propargyl230.34≥95% Pricing
AP11178THP-SS-alcohol238.36≥95% Pricing
AP13724(S)-2-amino-4-(2-(pyridin-2-yl)disulfanyl)butanoic acid244.3≥95% Pricing
AP11155t-Boc-Cystamine252.39≥95% Pricing
AP11163Propargyl-PEG1-SS-PEG1-acid264.35≥95% Pricing
AP11006N-Boc-Aminoethane-SS-acetic acid267.36≥95% Pricing
AP11172Boc-aminooxy-ethyl-SS-propanol269.37≥95% Pricing
AP14566N-(2,2,2-Trifluoroacetyl)-3-[(2-aminoethyl)dithio]propanoic acid277.30≥95% Pricing
AP11171Boc-NH-ethyl-SS-propionic acid281.39≥95% Pricing
AP11001Azido-SS-PEG2-acid295.37≥95% Pricing
AP11157Azidoethyl-SS-propionic NHS ester304.34≥95% Pricing
AP111812-hydroxyethyl disulfide mono-Tosylate308.43≥95% Pricing
AP15267Azido-PEG3-SS-amine310.44≥95% Pricing
AP15176Amino-PEG3-SS-acid313.44≥95% Pricing
AP11166Propargyl-PEG1-SS-PEG1-t-butyl ester320.46≥95% Pricing
AP15174Alkyne-PEG4-SS-amine323.48≥95% Pricing
AP11175Mal-NH-ethyl-SS-propionic acid332.39≥95% Pricing
AP11161Azidoethyl-PEG2-t-Butyl ester351.48≥95% Pricing
AP11179THP-SS-PEG1-t-butyl ester366.53≥95% Pricing
AP14240Trifluoroacetamidoethyl-SS-propionic NHS ester374.40≥95% Pricing
AP11007Amino-ethyl-SS-PEG3-NHBoc384.55≥95% Pricing
AP11167Acid-PEG2-SS-PEG2-acid386.47≥95% Pricing
AP11180THP-SS-PEG1-Tos392.54≥95% Pricing
AP134814-Azide-TFP-Amide-SS-propionic acid398.4≥98% Pricing
AP11173Fmoc-NH-ethyl-SS-propionic acid403.51≥95% Pricing
AP10498Biotin-NH-CH2CH2-S-S-Pyr412.60≥95% Pricing
AP13585Biotin-SS-Amine HCl Salt415≥98% Pricing
AP11176Hydroxy-PEG3-SS-PEG3-alcohol418.56≥95% Pricing
AP11164Propargyl-PEG1-SS-PEG1-PFP ester430.4≥95% Pricing
AP13833NHS-PEG1-SS-PEG1-NHS436.4≥95% Pricing
AP11182Bis-Tos-(2-hydroxyethyl disulfide)462.61≥95% Pricing
AP11160Azido-PEG3-SS-PEG3-azide468.59≥95% Pricing
AP14196DBCO-S-S-acid468.60≥95% Pricing
AP11168Acid-PEG3-SS-PEG3-acid474.58≥95% Pricing
AP15175Alkyne-PEG4-SS-PEG4-alkyne494.67≥95% Pricing
AP11174Fmoc-NH-ethyl-SS-propionic NHS ester500.58≥95% Pricing
AP13873Azido-Phenyl-Amido-S-S-Sulfo-NHS525.50≥95% Pricing
AP11169Acid-PEG4-SS-PEG4-acid562.69≥95% Pricing
AP11183Biotin-bisamido-SS-NHS575.71≥95% Pricing
AP147204-Azide-TFP-Amide-SS-Sulfo-NHS597.50≥95% Pricing
AP11185Sulfo-NThiol-SS-biotin606.67≥95% Pricing
AP11177m-PEG6-SS-PEG6-methyl622.83≥95% Pricing
AP11083Biotin-PEG3-SS-azide692.91≥95% Pricing
AP11153Amino-SS-PEG12-acid709.9≥95% Pricing
AP11170Acid-PEG6-SS-PEG6-acid738.9≥95% Pricing
AP13557Biotin-PEG4-S-S-NHS751.9≥98% Pricing
AP11068DBCO-S-S-PEG3-biotin869.12≥95% Pricing
AP13480Biotin-PEG4-S-S-acid654.9≥98% Pricing

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