Gly-Gly-Gly-PEG4-DBCO (CAS: 2353409-80-8) is a cleavable PEG linker designed for bioconjugation and drug delivery applications. It combines a tripeptide sequence (Gly-Gly-Gly) for controlled cleavage and a DBCO group for copper-free click chemistry with azide-containing molecules.
Key Features:
- Functional Groups: Gly-Gly-Gly for cleavability and DBCO for strain-promoted azide-alkyne cycloaddition (SPAAC).
- Molecular Formula: C₃₅H₄₆N₆O₉
- Molecular Weight: 694.77 g/mol
- Purity: Typically ≥95%
Applications:
- Antibody-Drug Conjugates (ADCs): Works as a cleavable linker, attaching therapeutic agents to antibodies for targeted drug delivery.
- Bioconjugation: Enables efficient conjugation of biomolecules through copper-free click chemistry.
- Protein Labeling: Allows for protein tagging and modification via the DBCO moiety.
- Click Chemistry Reactions: Supports SPAAC without a copper catalyst, ensuring biocompatibility and reduced cytotoxicity.
This linker is ideal for applications requiring precise, efficient, and biocompatible molecular assembly.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
