Methyltetrazine-PEG2-DBCO is a versatile bioconjugation reagent featuring two unique functional groups: methyltetrazine, a highly reactive moiety for click chemistry, and DBCO, an azide-reactive cyclooctyne. The presence of the PEG2 linker enhances solubility and reduces steric hindrance, making it an ideal choice for conjugating biomolecules, such as proteins, peptides, and nucleic acids.
Introduction to the application:
In pharmaceutical research and development, Methyltetrazine-PEG2-DBCO serves as a powerful tool for designing targeted therapeutics and imaging agents. Its rapid, bioorthogonal click chemistry enables the site-specific conjugation of biomolecules, resulting in precise modifications with minimal disturbance to native functionality. This facilitates the development of antibody-drug conjugates, bioactive small molecules, and nanoparticle-based drug delivery systems, ultimately advancing precision medicine and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.