Methyltetrazine-PEG-DBCO(DBCO-PEG-Methyltetrazine) is a versatile molecule with several functional groups that make it a valuable tool in drug research and development. It is a conjugate of tetrazine, a nitrogen-rich heterocyclic compound, and polyethylene glycol (PEG), a biocompatible polymer that can increase drug solubility and circulation time. The conjugate also contains a cyclooctyne group, known as DBCO, which can react with azide-containing molecules through a highly specific and efficient click chemistry reaction.
Methyltetrazine-PEG-DBCO is widely used in drug research and development due to its ability to selectively label and image biological molecules and cells in vitro and in vivo. It can also serve as a drug delivery system by encapsulating therapeutic agents and targeting specific cells or tissues through the click reaction.