Phosphonate PEG

Phosphonate PEG linkers, PEG Phosphonate are a class of chemical compounds that have gained significant attention in the field of pharmaceutical research and development. These compounds consist of a polyethylene glycol (PEG) chain attached to a phosphonate functional group (-PO3H2) via a linker molecule.

PEG phosphonic acids are widely used in surface modification to improve stability, biocompatibility and other physiochemical properties. For instance, m-PEG phosphonic acid was able to modify LLZO surface and results a membrane for better interfacial contact, better cyclability and in higher ionic conductivity in solid-state Li metal batteries.

Phosphonate PEG linkers are commonly used as a means of covalently linking drugs or other molecules to proteins or peptides, allowing for the targeted delivery of therapeutic agents to specific tissues or cells. The phosphonate group can form stable bonds with metal ions, such as calcium, which are often present in disease-related tissues or cells.

In addition to drug delivery applications, They have also been utilized in the development of imaging agents and diagnostic tools. The ability of the phosphonate group to chelate metal ions allows for the creation of contrast agents that can be used in imaging techniques, such as magnetic resonance imaging (MRI) or positron emission tomography (PET).

Ref: Enhancing the Performance of Ceramic-Rich Polymer Composite Electrolytes Using Polymer Grafted LLZO Pierre Ranque 1 , Jakub Zagórski 1 , Grazia Accardo 1 , Ander Orue Mendizabal 1 , Juan Miguel López del Amo 1 , Nicola Boaretto 1 , Maria Martinez-Ibañez 1 , Hugo Arrou-Vignod 1,2, Frederic Aguesse 1 , Michel Armand 1 and Shanmukaraj Devaraj 1,*