Branched Linkers have drawn much of attention in ADC research and development. It provides researchers an opportunity to get higher concentration of ADC payloads to the target cell per unit of binding antibody by improving DAR.
Branched and multi-arm PEG have improved aqueous solubility. Therefore, they help prevent ADC conjugate from aggregation or losing binding affinity. The combined benefits of PEG and branching effects enable conjugation of hydrophobic drugs at a higher DAR ratio than SPDB and SMCC linkers.
AxisPharm stocks a diversified collection of branched or multi-arm PEG reagents in our San Diego site. Furthermore, we are well equipped to provide custom synthesis of multi-arm ADC linkers to facilitate ADC research.