Unlock the Future of Chemical Synthesis
Welcome to the forefront of chemical innovation with our premium Tetrazine Linker. Engineered for precision and versatility, this powerful reagent is the key to unlocking new possibilities in chemical synthesis, bio-conjugation, and material science.
The Tetrazine ligation is the reaction of a trans-cyclooctene and a Tetrazine in an inverse electron demand Diels Alder (IEDDA) reaction followed by a retro-Diels Alder reaction to eliminate nitrogen gas. This is a fast reaction with a second-order rate constant of 2000 M−1-s−1 (in 9:1 methanol/water). It allows modification of biomolecules at very low concentrations. This ligation can be performed in aqueous media at a very fast speed. Reactions have also been performed using TCO or norbornenes as dienophiles at second-order rates on the order of 1 M−1–s−1 in aqueous media. The reaction has been applied in labeling live cells and other bio-entities.
Ref:
- Segawa, S., Wu, J., Kwok, R.T., Wong, T.T., He, X. and Tang, B.Z., 2024. Co‐aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On‐Demand Fluorogen Selection. Angewandte Chemie International Edition, 63(11), p.e202313930.
AxisPharm offers a wide range of high-purity Tetrazine, Tetrazine-PEG reagents with different linker lengths. Custom synthesis of Tetrazine PEG linkers are available upon request.
Why Choose Tetrazine Linker?
1. Exceptional Versatility Our Tetrazine Linker offers unparalleled flexibility for a range of applications, from advanced chemical synthesis to sophisticated biomolecular interactions. Whether you’re developing new materials or exploring novel reaction pathways, our linker adapts to your needs.
2. High Reactivity Featuring outstanding reactivity with trans-cyclooctenes (TCOs), our Tetrazine Linker ensures rapid and efficient click reactions. Its high specificity minimizes unwanted side reactions, delivering cleaner results and higher yields in your synthesis projects.
3. Precision Engineering Our Tetrazine Linker is meticulously engineered to provide precise control over linkage and conjugation processes. With rigorous quality control, you can trust our product to meet your exacting standards and deliver consistent performance.
4. Robust Performance Designed for resilience, our Tetrazine Linker performs reliably across a wide range of conditions. Its stability and compatibility with diverse solvents and reagents make it an indispensable tool in both laboratory and industrial settings.
Applications
- Chemical Synthesis: Facilitate complex molecule assembly with ease and accuracy.
- Bio-Conjugation: Achieve precise labeling and targeting for biomedical research and drug development.
- Material Science: Enhance the development of novel materials with innovative cross-linking strategies.
- Imaging and Detection: Improve the specificity and sensitivity of imaging agents and diagnostic tools.
Product Features
- Chemical Structure: Optimized for superior reactivity and stability.
- Purity: High-purity grades available to ensure the highest quality results.
- Packaging: Available in various sizes to suit your needs, from small-scale experiments to large-scale production.
