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Cleavable linkers play a crucial role in the success of antibody-drug conjugates. It determines the fate of the cytotoxic drug in the biological system. In order to make the ADC effective, it requires the linkers to be stable enough in the blood circulation for a substantial amount of time to avoid side toxicity and to allow ADC to reach the target. It also requires the linkers to be labile so that they efficiently release corresponding payload in the tumor environment.

Cleavable Linkers
  • β-Glucuronide Linkers
  • Dde Cleavable Linkers
  • diazo biotin probes
Catalog# Name Structure M.W. Purity Pricing
β-Glucuronide Linkers
AP10901β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine748.74≥95% Pricing
AP10975β-tetraacetylglucopyranoside-glycerol422.38≥95% Pricing
AP10974β-tetraacetylglucopyranoside-glycol392.36≥95% Pricing
AP10153(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate913.84≥95% Pricing
AP101524-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate483.38≥95% Pricing
AP10154β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate455.42≥95% Pricing
Dde Cleavable Linkers
AP11058Dde Biotin-PEG4-alkyne650.83≥95% Pricing
AP11048Dde Biotin-PEG4-azide695.88≥95% Pricing
AP11049Dde Biotin-PEG4-Picolyl azide815.99≥95% Pricing
AP11070Dde Biotin-PEG4-DBCO872.09≥95% Pricing
diazo biotin probes
AP11050Diazo Biotin-PEG3-azide711.84≥95% Pricing
AP11059Diazo Biotin-PEG3-alkyne795.95≥95% Pricing
AP11067Diazo Biotin-PEG3-DBCO973.16≥95% Pricing