Cleavable linkers play a crucial role in the success of antibody-drug conjugates. It determines the fate of the cytotoxic drug in the biological system. In order to make the ADC effective, it requires the Cleavable linkers to be stable enough in the blood circulation for a substantial amount of time to avoid side toxicity and to allow ADC to reach the target. It also requires the linkers to be labile so that they efficiently release corresponding payload in the tumor environment.
Axispharm offers over 3000 ADC Linkers with high purity. Different kinds of antibody-drug conjugates Reagents may be available by custom synthesis.