Bioconjugation Service

AxisPharm Bioconjugation Services

Transform Your Molecules with Precision and Expertise

At AxisPharm, we offer high-quality, custom bioconjugation services that enhance drug efficacy and improve drug properties. Our advanced techniques and expert team are here to support your research and development needs with precision and affordability.

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Why Choose AxisPharm for Bioconjugation?

1. Expertise and Innovation

• Cutting-Edge Techniques: We use advanced methods for linking biomolecules and polymers, including PEGylation, antibody-drug conjugates (ADCs), and more.
• Experienced Team: Our specialists bring extensive knowledge and experience to deliver outstanding results.

 

2. Comprehensive Bioconjugation Services

• Early De-risking and Optimization: Address potential challenges early to optimize your conjugation process.
• Process Development and Optimization: Customize and refine your bioconjugation process for efficiency and scalability.
• Formulation Development: Create stable and effective formulations for your bioconjugation products.
• Analytical Method Development: Develop and validate methods to accurately characterize and control quality.
• Drug Manufacture: Handle both drug substance and product manufacture with precision.
• Payload and Linker Manufacturing: Produce high-quality payloads and linkers tailored to your needs.

 

3. Diverse Conjugation Techniques

• Antibody-Drug Conjugates (ADCs): Enhance therapeutic efficacy with targeted ADCs.
• Antibody-Oligonucleotide Conjugates (AOCs): Develop specialized conjugates for advanced applications.
• Protein-Drug Conjugation: Improve drug delivery with protein-drug conjugates.
• Fluorophore Conjugation: Utilize fluorescent dyes for imaging and detection.
• Biotin Conjugation: Incorporate biotin linker for versatile assays and detection.
• Polymer-Drug Conjugation: Enhance drug properties with polymer-PEG conjugates.
• Polymer-Drug-Target Ligand Conjugation: Design targeted conjugates for precise drug delivery.
• PEGylation and Cross-Linking: Improve solubility and stability with PEGylation.
• Cysteine-Based and Lysine-Based Conjugation: Apply these methods for specific needs.
• Thio-Engineered Antibodies: Develop specialized antibodies with enhanced features.
• Carbohydrate-Based Conjugation: Conjugate carbohydrates for unique applications.
• Unnatural Amino Acids-Based Conjugation: Use unnatural amino acids, such as amino-PEG, for innovative strategies.

 

4. Analytical Excellence

• Advanced Mass Spectrometry: Our high-resolution mass spectrometers provide real-time analysis and quantification of proteins, antibodies, and other conjugates.
• Real-Time Analysis: Perform drug-antibody ratio analysis for process optimization and quality control. See our real-time analysis case study.

 

5. Synthetic Chemistry and Biology Expertise

• Extensive Inventory: Access a broad range of ADC linkers, including PEG, peptide, sugar, and dye probes.
• Comprehensive Services: Benefit from our expertise in synthesizing, purifying, and characterizing both small and large molecules.

 

Expertise and Innovation

• Cutting-Edge Techniques: We use advanced methods for linking biomolecules and polymers, including PEGylation, antibody-drug conjugates (ADCs), and more.
• Experienced Team: Our specialists bring extensive knowledge and experience to deliver outstanding results.

 

Ref:

Nina Hentzen1, Abbas El Sahili2, Julien Lescar2, Chuan Fa Liu2 & Raphael Frey1 Bioconjugation Technology Selection during Early-Stage Development – A Strategy to Streamline IND and Manufacturing Timelines – J. ADC. May 26, 2023. DOI: 10.14229/jadc.2023.07.10.002.