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SPDP PEG linker is a PEG reagent(crosslinker) , which have a reducible (cleavable) disulfide bond. Pyridyldithiol group enables disulfide linkage with reduced cysteines and other sulfhydryl groups, providing a stable but cleavable bond.
The containing polyethylene glycol (PEG) spacer arms offer greater solubility to the crosslinker and the linked proteins compared to crosslinkers having only hydrocarbon spacers. SPDP reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT).
Axispharm offers a range of high purity SPDP PEG reagents with different linker lengths.Different kinds of PEG Reagents may be available by custom synthesis. Fast delivery – Overnight shipping.

SPDP PEG
  • SPDP-PEG-acid
  • SPDP-PEG-NHS-ester
  • SPDP-PEG-t-Butyl ester
  • SPDP-PEG-TCO
Catalog# Name Structure M.W. Purity Pricing
SPDP-PEG-acid
AP10427SDPD-PEG4-acid462.58≥95% Pricing
AP10428SDPD-PEG5-acid506.63≥95% Pricing
AP10429SDPD-PEG7-acid594.74≥95% Pricing
AP10038SPDP-PEG8-acid638.79≥98% Pricing
AP10430SDPD-PEG8-acid682.84≥95% Pricing
AP11430SPDP-PEG12-acid815≥95% Pricing
AP11431SPDP-PEG24-acid1343.64≥95% Pricing
AP11432SPDP-PEG36-acid1872.27≥95% Pricing
AP108614-methyl-4-(pyridin-2-yldisulfaneyl)pentanoic acid257.37≥95% Pricing
SPDP-PEG-NHS-ester
AP11433SPDP-PEG4-NHS ester559.65≥95% Pricing
AP11434SPDP-PEG6-NHS ester647.76≥95% Pricing
AP11435SPDP-PEG8-NHS ester735.86≥95% Pricing
AP11436SPDP-PEG12-NHS ester912.07≥95% Pricing
AP108672,5-dioxopyrrolidin-1-yl 4-methyl-4-(pyridin-2-yldisulfaneyl)pentanoate354.44≥95% Pricing
SPDP-PEG-t-Butyl ester
AP10037SPDP-PEG8-tBu ester694.90≥98% Pricing
SPDP-PEG-TCO
AP10144SPDP-NH-PEG2-TCO497.67≥95% Pricing