The HyNic PEG linker features a 6-HydrazinoNicotinamide (HyNic) group, a PEG spacer, and a functional end. It reacts with 4-FormylBenzamide-modified biomolecules to form stable hydrazone bonds. The PEG spacer boosts water solubility, enhances flexibility, and reduces aggregation, making it ideal for bioconjugation, ADC development, and diagnostic applications.
AxisPharm provides multi functionalized HyNic PEG linkers with high purity. Custom synthesis of HyNic PEG reagents and bioconjugation services are available upon request.
HyNic PEG
HyNic PEG Linker
The HyNic PEG linker combines a 6-HydrazinoNicotinamide (HyNic) on one end, a PEG spacer in the middle, and a functional group on the other. It specifically reacts with 4-FormylBenzamide-modified biomolecules to form stable hydrazone bonds. The PEG spacer boosts water solubility, making the bioconjugates more effective in biological applications.Key Features
- HyNic Group: The HyNic end reacts with 4-FormylBenzamide, forming a stable bond under mild conditions.
- PEG Spacer: The PEG chain increases water solubility and provides flexibility. It also reduces aggregation, improving the performance of the conjugates.
- Dual Functional Ends: Offers a functional group at the other end for further modifications.
Applications
- Bioconjugation: Links proteins, peptides, and other molecules to drugs, labels, or probes.
- Antibody-Drug Conjugates (ADCs): Connects antibodies to drug payloads for targeted therapies.
- Diagnostics and Imaging: Attaches tracers to targeting molecules for probes and imaging agents.
- Surface Modification: Adds biomolecules to surfaces for better biocompatibility or functionalization.
Advantages
- Enhanced Solubility: The PEG spacer significantly improves water solubility, making it suitable for biological environments.
- Specific Conjugation: Forms stable hydrazone bonds with 4-FormylBenzamide, ensuring precise and controlled linking.
- Adjustable Linker Lengths: Available in different PEG sizes to customize the distance between linked molecules.
Product Options
- Custom Modifications: Tailored options for specific applications or additional functional groups.