Phosphoramidites are a class of organic compounds that contain a phosphorous atom and an amino group connected through an alkyl or aryl group. They are widely used in the synthesis of oligonucleotides, which are short DNA or RNA molecules. The key process in the synthesis of oligonucleotides using phosphoramidites is the controlled removal of the protecting groups and the addition of the next nucleotide in the sequence. This iterative process allows for the synthesis of highly specific and pure oligonucleotides for use in various applications, such as gene therapy and drug development. Two keywords commonly associated with phosphoramidites are “oligonucleotide synthesis” and “protecting group chemistry”.