DBCO-PEG24-amine TFA salt is a bifunctional linker featuring an azide-reactive dibenzocyclooctyne (DBCO) moiety, a polyethylene glycol (PEG) spacer, and a primary amine group. The amine functionality enables conjugation with carboxylic acid groups, while the DBCO moiety facilitates strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioorthogonal conjugations.
Introduction to the Application: Utilized in pharmaceutical R&D, DBCO-PEG24-amine TFA salt serves as an effective linker in the development of targeted drug delivery systems, bioconjugates, and biomaterials. Its unique bifunctional nature enables the covalent attachment of bioactive molecules and the creation of hydrophilic, biocompatible constructs, improving drug solubility, stability, and pharmacokinetic properties, while minimizing side effects.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.