Cleavable PEG Reagents play a crucial role in the success of antibody-drug conjugates. It determines the fate of the cytotoxic drug in the biological system. In order to make the ADC effective, it requires the Cleavable reagents to be stable enough in the blood circulation for a substantial amount of time to avoid side toxicity and to allow ADC to reach the target. It also requires the reagents to be labile so that they efficiently release corresponding payload in the tumor environment.
Axispharm provides functionalized cleavable PEGs with disulfide bonds or photocleavable bonds. Different kinds of antibody-drug conjugates Reagents may be available by custom synthesis.