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PTAD linkers target tyrosine residues with high selectivity. They often include azide, alkyne, or amine groups for versatile conjugation. These linkers provide stability and work well in biological environments, making them ideal for targeted labeling, drug delivery, and biosensors.

PTAD Linker

Cat# Name Structure M.W. Purity Pricing
AP15477PTAD-alkyne261.23≥90% Pricing
AP15474PTAD-azide292.25≥95% Pricing
AP15480Methoxyl-PTAD-amine.HCl302.72≥95% Pricing
AP15478PTAD-PEG4-alkyne508.52≥95% Pricing
AP15479PTAD-PEG4-amine513.54≥95% Pricing
AP15476PTAD-PEG4-azide539.54≥95% Pricing

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    PTAD Linkers: Overview and Applications

    Product Summary
    PTAD (4-Phenyl-3H-1,2,4-triazoline-3,5(4H)-dione) linkers are versatile bioconjugation tools designed for selective labeling, particularly targeting tyrosine residues in proteins, peptides, and small molecules. PTAD linkers often feature additional functional groups, such as azide, alkyne, or amine, that enable click chemistry or other conjugation reactions. These linkers offer high selectivity, stability, and compatibility in various biological environments, making them valuable in research, diagnostics, and therapeutic applications.


    Key Benefits of PTAD Linkers

    • Selective Tyrosine Targeting: Binds specifically to tyrosine residues, minimizing interactions with other amino acids.
    • Dual Functionality: Often includes additional functional groups (e.g., azide, alkyne, amine) for versatile conjugation options.
    • High Stability: PTAD modifications enhance stability in different biological conditions.
    • Bioorthogonal Compatibility: Works in aqueous environments without interfering with other biological processes.

    Applications of PTAD Linkers

    1. Bioconjugation and Labeling
      • Enables selective and stable labeling of tyrosine residues for protein and peptide tracking.
    2. Click Chemistry and Conjugation
      • Functional groups like azide or alkyne allow click chemistry reactions (CuAAC) for precise, bioorthogonal bioconjugation.
    3. Drug Delivery and Targeted Therapy
      • Facilitates targeted attachment of therapeutic agents, improving precision in drug delivery.
    4. Surface Functionalization
      • Ideal for modifying surfaces with bioactive molecules, enhancing biosensor sensitivity and diagnostic applications.