DBCO-PEG5-TFP Ester contains a DBCO and a TFP group. The active TFP ester is more stable than NHS ester and less prone to hydrolysis in aqueous meida and can be used to label amine bearing proteins, antibodies, and other biopolymers. The hydrophilic polyethylene glycol (PEG) spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to azide-containing molecules.
DBCO reagents are the most commonly used substrates for strain-promoted azide-alkyne click chemistry. DBCO compounds react with azide-tagged biomolecules quickly in high yield without using a Cu(I) catalyst or elevated temperature to result in a stable triazole linkage, making the DBCO bearing compounds perfect candidates for parrell synthesis.
AxisPharm offers 4000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.