Sugar PEG β-Glucuronide Linker

Sugar PEG linkers can be used in bio-molecule design for their immuno-suppression effects. AxisPharm provides high purity Sugar PEG reagents with various active groups, including azide, bromide, etc.

β-Glucuronide linkers have been employed to prepare ADCs composed of several drug classes, such as auristatins, camptothecin and doxorubicin analogues, CBI minor-groove binders, and psymberin. Facile release of the active drug can be achieved through cleavage of the b-glucuronide glycosidic bond by the lysosomal enzyme b-glucuronidase (GUSB). GUSB is abundant in lysosomes and is overexpressed in some tumor types but has low activity outside cells. These features allow ADCs with β-Glucuronide linkers remain high stability in systemic circulation and selectively release active drugs intracellularly through hydrolysis by β-glucuronidase.

β-glucuronide is highly hydrophilic and it may help avoid aggregation of some ADCs that incorporate highly hydrophobic drugs.