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TCO PEG Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.

The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.

Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.
AxisPharm has large production capacity for high quality TCO PEG reagents with amine, aminooxy, NHS ester and acid functionality. We also provide custom synthesis of PEG linkers modified folate, biotin and fluorescent dye for biological applications.

Cat# Name Structure M.W. Purity Pricing
Bromoacetamido-PEG-TCO
AP13224Bromoacetamido-PEG3-TCO493.4≥96% Pricing
Diazo-PEG-TCO
AP13225Diazo-PEG3-TCO 794≥98% Pricing
HyNic-PEG-TCO
AP10599HyNic-PEG2-TCO475.59≥95% Pricing
AP10608HyNic-PEG3-TCO535.64≥95% Pricing
M-PEG-TCO
AP13226m-PEG4-TCO359.5≥98% Pricing
N-Methylaniline-PEG-TCO
AP13227N-Methylaniline-PEG3-TCO519.7≥98% Pricing
Other-TCO-PEG
AP10598TCO-PEG1-Br233.15≥95% Pricing
AP13060TCO-tBu ester254.37≥95% Pricing
AP10601TCO-NHS Acetate281.30≥95% Pricing
AP10002TCO-PNP291.3≥95% Pricing
AP10602TCO-PEG1-Tosyl (axial)324.44≥95% Pricing
AP10039TCO PEG3 CH2CO2H359.42≥98% Pricing
AP10141Aminooxy-PEG2-TCO HCl Salt in solution373.45≥95% Pricing
AP10040TCO PEG3 CH2CONHS456.49≥98% Pricing
AP10142Bocaminooxy-PEG2-TCO473.57≥95% Pricing
AP13233BDP FL-PEG4-TCO662.6≥95% Pricing
SPDP-PEG-TCO
AP10144SPDP-NH-PEG2-TCO497.67≥95% Pricing
TCO-carbonylamino-benzamido-PEG acid
AP10851TCO-carbonylamino-benzamido-PEG1 acid404.46≥95% Pricing
AP10852TCO-carbonylamino-benzamido-PEG2 acid448.51≥95% Pricing
AP10853TCO-carbonylamino-benzamido-PEG3 acid492.56≥95% Pricing
AP10847TCO-carbonylamino-benzamido-PEG1 NHS ester501.53≥95% Pricing
AP10854TCO-carbonylamino-benzamido-PEG4 acid536.61≥95% Pricing
TCO-carbonylamino-benzamido-PEG4 NHS ester
AP10848TCO-carbonylamino-benzamido-PEG2 NHS ester545.58≥95% Pricing
AP10849TCO-carbonylamino-benzamido-PEG3 NHS ester589.64≥95% Pricing
AP10850TCO-carbonylamino-benzamido-PEG4 NHS ester633.69≥95% Pricing
TCO-carbonylamino-benzyl NHS ester
AP10846TCO-carbonylamino-benzyl NHS ester386.40≥95% Pricing
TCO-OH & TCO-PEG-OH
AP10001TCO-OH126.2≥95% Pricing
AP10033TCO-OH (equatorial)126.2≥98% Pricing
AP10034TCO-OH (axial)126.2≥98% Pricing
AP10046TCO-PEG1-OH170.25≥95% Pricing
AP10597TCO-PEG1-OH (axial)170.25≥95% Pricing
AP10679TCO-PEG1-OH (equatorial)170.25≥95% Pricing
AP13066TCO-propanol184.28≥95% Pricing
TCO-PEG-Acid
AP10600TCO-Acetic acid184.24≥95% Pricing
AP13061TCO-acid198.26≥95% Pricing
AP13053TCO-benzoic acid260.33≥95% Pricing
AP10808TCO-PEG1-acid285.34≥95% Pricing
AP10809TCO-PEG2-acid329.39≥95% Pricing
AP10810TCO-PEG3-acid373.44≥95% Pricing
AP10100TCO-PEG4-CH2 acid403.47≥95% Pricing
AP10811TCO-PEG4-acid417.5≥95% Pricing
AP10098TCO-PEG5 acid461.55≥95% Pricing
AP10813TCO-PEG6-acid505.60≥95% Pricing
AP10814TCO-PEG7-acid549.66≥95% Pricing
AP11855TCO-PEG8-acid593.71≥95% Pricing
AP13220TCO-PEG10-acid681.8≥95% Pricing
AP10743TCO-PEG12-acid769.92≥95% Pricing
AP11856TCO-PEG24-acid1298.56≥95% Pricing
AP11857TCO-PEG36-acid1827.2≥95% Pricing
TCO-PEG-alcohol
AP13222TCO-PEG3-alcohol301.4≥95% Pricing
TCO-PEG-ald
AP13064TCO-ald182.26≥95% Pricing
AP10103TCO-PEG3-CH2-ald343.42≥95% Pricing
AP10143Ald-benzyl-amine-PEG2-TCO432.52≥95% Pricing
TCO-PEG-Amine
AP11864TCO-amine hydrochloride226.32≥95% Pricing
AP10829TCO-PEG1-amine256.34≥95% Pricing
AP12564TCO-Amine, HCl Salt262.78≥95% Pricing
AP11866TCO-C3-PEG3-C3-amine281.37≥0.95 Pricing
AP10830TCO-PEG2-amine300.39≥95% Pricing
AP10831TCO-PEG3-amine344.45≥95% Pricing
AP10832TCO-PEG4-amine388.50≥95% Pricing
AP10833TCO-PEG5-amine432.55≥95% Pricing
AP10834TCO-PEG6-amine476.60≥95% Pricing
AP10835TCO-PEG7-amine520.66≥95% Pricing
AP11865TCO-PEG8-amine564.72≥95% Pricing
AP13217TCO-PEG12-amine740.9≥95% Pricing
AP13218TCO-PEG23-amine1225.5≥95% Pricing
AP13928TCO-PEG24-amine1269.5≥95% Pricing
TCO-PEG-BCN
AP11029TCO-PEG5-BCN608.76≥95% Pricing
TCO-PEG-biotin
AP10836TCO-PEG1-Biotin482.64≥95% Pricing
AP10837TCO-PEG2-Biotin526.69≥95% Pricing
AP10838TCO-PEG3-Biotin570.74≥95% Pricing
AP11867TCO-PEG4-biotin614.8≥95% Pricing
AP10839TCO-PEG5-Biotin658.85≥95% Pricing
AP14141TCO-PEG8-Biotin791.00≥95% Pricing
AP14142TCO-PEG12-Biotin967.20≥95% Pricing
TCO-PEG-DBCO
AP11027TCO-PEG1-amido-DBCO543.65≥95% Pricing
AP10842TCO-PEG2-DBCO587.71≥95% Pricing
AP10843TCO-PEG3-DBCO631.76≥95% Pricing
AP11028TCO-PEG4-DBCO675.8≥95% Pricing
AP10845TCO-PEG5-DBCO719.86≥95% Pricing
AP13185TCO-PEG6-DBCO763.9≥95% Pricing
AP13186TCO-PEG8-DBCO852≥95% Pricing
AP10742TCO-PEG12-DBCO1028.23≥95% Pricing
AP13187TCO-PEG24-DBCO1556.9≥95% Pricing
TCO-PEG-Maleimide
AP10822TCO-PEG1-maleimide336.38≥95% Pricing
AP10823TCO-PEG2-maleimide380.44≥95% Pricing
AP10801TCO-PEG1-amido maleimide407.46≥95% Pricing
AP10824TCO-PEG3-maleimide424.49≥95% Pricing
AP10802TCO-PEG2-amido maleimide451.51≥95% Pricing
AP12629Sulfo TCO-Maleimide457.5≥95% Pricing
AP10825TCO-PEG4-maleimide468.54≥95% Pricing
AP10803TCO-PEG3-amido maleimide495.57≥95% Pricing
AP10826TCO-PEG5-maleimide512.59≥95% Pricing
AP12560TCO-C3-PEG3-C3-Amido-Maleimide523.62≥95% Pricing
AP10804TCO-PEG4-amido maleimide539.62≥95% Pricing
AP10827TCO-PEG6-maleimide556.65≥95% Pricing
AP10805TCO-PEG5-amido maleimide583.67≥95% Pricing
AP10828TCO-PEG7-maleimide600.71≥95% Pricing
AP10806TCO-PEG6-amido maleimide627.72≥95% Pricing
AP10807TCO-PEG7-amido maleimide671.78≥95% Pricing
AP10744TCO-PEG9-maleimide759.88≥95% Pricing
TCO-PEG-NHS ester
AP13857TCO-NHS Ester (equatorial)267.28≥95% Pricing
AP12681TCO-NHS Ester (axial)267.28≥95% Pricing
AP10003TCO-NHS ester267.30≥95% Pricing
AP13056TCO-benzoyl-NHS ester357.4≥95% Pricing
AP10815TCO-PEG1-NHS ester382.41≥95% Pricing
AP10816TCO-PEG2-NHS ester426.46≥95% Pricing
AP10817TCO-PEG3-NHS ester470.52≥95% Pricing
AP10101TCO-PEG4-CH2 NHS ester500.54≥95% Pricing
AP10818TCO-PEG4-NHS ester514.57≥95% Pricing
AP13228TCO-PEG2-Sulfo-NHS ester528.5≥95% Pricing
AP10099TCO-PEG5 NHS ester558.62≥95% Pricing
AP10820TCO-PEG6-NHS ester602.67≥95% Pricing
AP10821TCO-PEG7-NHS ester646.73≥95% Pricing
AP11858TCO-PEG8-NHS ester690.78≥95% Pricing
AP11859TCO-PEG12-NHS ester867≥95% Pricing
AP11860TCO-PEG24-NHS ester1395.63≥95% Pricing
AP13221TCO-PEG36-NHS ester1924.3≥95% Pricing
TCO-PEG-oxyamine
AP10105TCO-PEG2-oxyamine316.39≥95% Pricing
AP10104TCO-PEG3-oxyamine360.45≥95% Pricing
AP10107TCO-PEG2-oxyamineBoc416.51≥95% Pricing
AP10106TCO-PEG3-oxyamineBoc460.56≥95% Pricing
TCO-PEG-peptide
AP11871Gly-Gly-Gly-PEG3-TCO515.61≥95% Pricing
AP13232TCO-PEG4-Fmoc-Gly-Gly-Gly781.9≥95% Pricing
TCO-PEG-PNB
AP11863TCO-PNB Ester291.3≥95% Pricing
TCO-PEG-silane
AP10102TCO-triethoxysilane373.56≥95% Pricing
TCO-PEG-TCO (Bis-TCO PEG)
AP10840TCO-PEG2-TCO452.59≥95% Pricing
AP11868TCO-PEG3-TCO496.65≥95% Pricing
AP11869TCO-PEG4-TCO540.7≥95% Pricing
AP10841TCO-PEG5-TCO584.74≥95% Pricing
AP13219TCO-PEG6-TCO628.8≥95% Pricing
AP11870TCO-PEG8-TCO716.91≥95% Pricing
AP13231TCO-PEG-TCO, MW 5K5000≥95% Pricing
TCO-PEG-TFP ester
AP12645TCO-PEG4-TFP Ester565.56≥95% Pricing
AP11861TCO-PEG8-TFP ester741.77≥95% Pricing
AP11862TCO-PEG12-TFP ester917.98≥95% Pricing
TCO-PEG-triethoxysilane
AP13081TCO-trimethoxysilane331.48≥95% Pricing
AP11835TCO-PEG3-triethoxysilane576.8≥95% Pricing

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