DBCO-acid CAS:1353016-70-2 is a chemical compound belonging to the class of diazobenzene-carboxylic acid derivatives. It contains a carboxylic acid functional group (-COOH) and a strained cyclooctyne moiety, which is capable of rapidly reacting with azides via a copper-free click chemistry reaction.
DBCO-acid is a popular building block for DBCO derivatization. The acid group can react with amine to form amide bond under coupling conditons in the presence of activators such as EDC, DCC and HATU. DBCO. On the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-acid has been widely used in drug discovery and development processes as a bioconjugation reagent for attaching drugs to specific targeting molecules such as antibodies, peptides, and nucleic acids. Its ability to react efficiently and selectively with azide-containing molecules, such as fluorophores and biomolecules, has made it an essential tool for the development of targeted drug delivery systems and diagnostic agents.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.