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PEG NHS ester linkers have been widely usded for crosslinking or labeling peptides and proteins. They readily react with primary amine groups at the N-terminus of polypeptide chains and lysine amino groups. These primary amines exist predominantly on the outside surfaces of protein and are readily accessible to NHS ester for bioconjugations. In addition, these primary amines are nucleophilic enough to react with PEG-NHS esters for protein crosslinking and labeling.

The functional groups on the other end of the linkers provide protein scientist opportunities for further conjugation with other biomolecules or drug targets.

Incorporating a PEG spacer can dramatically improve the solubility of the linker and make them ideal for ADC conjugations as most of the process take place in aqueous media.

AxisPharm maintain a large collection of high quality PEG NHS ester linkers for our clients to select. For custom synthesis of ADC linkers, please contact us. 

NHS ester PEG
Cat# Name Structure M.W. Purity Pricing
(2-pyridyldithio)-PEG-NHS ester
AP10769(2-pyridyldithio)-PEG4-NHS ester488.58≥95% Pricing
Acid-PEG-NHS ester
AP10913acid-PEG2-NHS ester303.27≥95% Pricing
AP11823Acid-PEG3-NHS ester347.32≥95% Pricing
AP11824Acid-PEG5-NHS ester435.43≥95% Pricing
AP11825Acid-PEG9-NHS ester611.64≥95% Pricing
AP11826Acid-PEG13-NHS ester787.85≥95% Pricing
AP11827Acid-PEG25-NHS ester1316.49≥95% Pricing
ald-benzoylamide-PEG-CH2 NHS ester
AP10068Ald-benzoylamide-PEG2-CH2 NHS ester392.36≥95% Pricing
AP10066Ald-benzoylamide-PEG3-CH2 NHS ester436.41≥95% Pricing
AP10064Ald-benzoylamide-PEG4-CH2 NHS ester480.47≥95% Pricing
Ald-PEG-NHS ester
AP12243Ald-Ph-PEG2-NHS406.39≥95% Pricing
AP12244Ald-Ph-PEG4-NHS ester494.5≥95% Pricing
AP12245Ald-Ph-PEG24-NHS ester1375.56≥95% Pricing
Azido-PEG-aminoacetic acid-NHS ester
AP11534Azido-PEG3-aminoacetic acid-NHS ester373.36≥95% Pricing
AP11528Azido-PEG1-CH2CO2-NHS242.19≥95% Pricing
AP11529Azido-PEG2-CH2CO2-NHS286.24≥95% Pricing
AP11530Azido-PEG3-CH2CO2-NHS330.29≥95% Pricing
AP11531Azido-PEG4-CH2CO2-NHS374.35≥95% Pricing
AP11532Azido-PEG5-CH2CO2-NHS418.40≥95% Pricing
AP11533Azido-PEG8-CH2CO2-NHS550.56≥95% Pricing
Azido-PEG-NHS ester
AP11522Azidoacetic acid NHS ester198.14≥95% Pricing
AP11523Azido-PEG1-NHS ester256.22≥95% Pricing
AP11524Azido-PEG2-NHS ester300.27≥95% Pricing

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