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PROTACs (PROteolysis TArgeting Chimeras) revolutionize drug development by breaking down disease-causing proteins instead of just blocking them. By harnessing the body’s natural degradation system, PROTACs offer targeted treatments for cancers, neurodegenerative diseases, and autoimmune disorders. With their ability to remove harmful proteins, PROTACs are leading the way in more effective and precise therapies.

Cat# Name Structure M.W. Purity Pricing
(S,R,S)-AHPC-amido-acid
AP14172(S,R,S)-AHPC-amido-C2-acid530.60≥95% Pricing
AP14171(S,R,S)-AHPC-amido-C6-acid586.80≥95% Pricing
(S,R,S)-AHPC-Boc
AP14173(S,R,S)-AHPC-Boc530.70≥95% Pricing
(S,R,S)-AHPC-Me-amine
AP14168(S,R,S)-AHPC-Me-C10-NH2627.90≥95% Pricing
(S,R. S)-AHPC-PEG-acid
AP13442(S,R,S)-AHPC-pentanoic-acid558.7≥98% Pricing
AP14164(S, R, S)-AHPC-nanoly-acid614.80≥95% Pricing
AP12132(S,R. S)-AHPC-PEG2-acid618.75≥95% Pricing
AP13438(S,R,S)-AHPC-PEG3-acid662.8≥98% Pricing
AP13439(S,R,S)-AHPC-PEG4-acid706.9≥98% Pricing
AP13440(S,R,S)-AHPC-PEG6-acid795≥98% Pricing
AP13441(S,R,S)-AHPC-PEG8-acid883≥98% Pricing
(S,R. S)-AHPC-PEG-amine
AP14170(S,R,S)-AHPC-C4-NH2529.70≥95% Pricing
AP14169(S,R,S)-AHPC-C6-NH2557.80≥95% Pricing
AP12133(S,R. S)-AHPC-PEG2-amine hydrochloride salt575.73≥95% Pricing
AP13954(S, R, S)-AHPC-PEG3-amine hydrochloride salt619.8≥95% Pricing
AP12134(S,R. S)-AHPC-PEG4-amine hydrochloride salt663.83≥95% Pricing
(S,R. S)-AHPC-PEG-Azide
AP12135(S,R. S)-AHPC-PEG4-Azide703.86≥95% Pricing
(S,R. S)-AHPC-PEG-NHS ester
AP13391(S,R,S)-AHPC-PEG2-NHS ester715.8≥98% Pricing
AP13392(S,R,S)-AHPC-PEG4-NHS ester803.9≥98% Pricing
AP13403(S,R,S)-AHPC-PEG6-NHS ester892≥95% Pricing
AP13404(S,R,S)-AHPC-PEG8-NHS ester980.2≥98% Pricing
(S,R. S)-AHPC-PEG-tosyl
AP14165(S, R, S)-AHPC-PEG2-Tos700.90≥95% Pricing
AP14166(S, R, S)-AHPC-PEG4-tosyl789.00≥95% Pricing
AP14167(S, R, S)-AHPC-PEG6-Tos877.10≥95% Pricing
4-Fluoro-thalidomide
AP121294-Fluoro-thalidomide276.22≥95% Pricing
4-Hydroxy-thalidomide
AP121224-Hydroxy-thalidomide274.23≥95% Pricing
ARV-110
AP14691ARV-110812.30≥95% Pricing
ARV-825
AP14692ARV-825923.5≥95% Pricing
BET Inhibitors
AP14266PFI 3321.40≥95% Pricing
AP14265PFI 1347.40≥95% Pricing
AP14256BI 9564353.40≥95% Pricing
AP14255BAZ2-ICR357.40≥95% Pricing
AP14253RVX-208370.40≥95% Pricing
AP14259GSK 2801371.50≥95% Pricing
AP14267PFI 4380.50≥95% Pricing
AP14251MS-436383.40≥95% Pricing
AP14263NI 57383.40≥95% Pricing
AP14260GSK 5959394.50≥95% Pricing
AP14258CPI 203399.90≥95% Pricing
AP14257Bromosporine404.50≥95% Pricing
AP14261GSK 6853409.50≥95% Pricing
AP14250I-BET 762423.90≥95% Pricing
AP14254BAY 299429.50≥95% Pricing
AP14272l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo [3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one438.50≥95% Pricing
AP14249(+)JQ-1457.00≥95% Pricing
AP142734-(4-(4-(3-fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)phenol471.90≥95% Pricing
AP14269XMD 8-92474.60≥95% Pricing
AP14264OTX 015492.00≥95% Pricing
AP14262I-BRD9497.60≥95% Pricing
AP14270N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine505.70≥95% Pricing
AP14268SGC-CBP30509.10≥95% Pricing
AP14252BI-2536521.70≥95% Pricing
AP14271dBET1785.3≥95% Pricing
BETd-260
AP14690BETd-260798.90≥95% Pricing
BTK kinase inhibitor
AP14294IBT6A386.50≥95% Pricing
E3 Ligand
AP14275LCL161500.60≥95% Pricing
AP14277Nutlin-3581.50≥95% Pricing
AP14276Idasanutlin616.50≥95% Pricing
E3 Ligase ligand
AP14439E3 Ligase ligand 9408.50≥95% Pricing
AP14437E3 Ligase ligand 1a444.60≥95% Pricing
AP14438E3 ligase Ligand 19532.60≥95% Pricing
Iberdomide
AP15055Iberdomide449.5≥95% Pricing
IKZF1/IKZF3 Degrader
AP15056CFT7455469.5≥95% Pricing
Lenalidomide
AP13829Phthalimidine, 2-(2,6-dioxopiperiden-3-yl)244.3≥95% Pricing
AP139693-(7-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione259.26≥95% Pricing
AP139703-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione259.26≥95% Pricing
AP139683-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione259.26≥95% Pricing
AP13967Lenalidomide259.26≥95% Pricing
AP13977Lenalidomide-OH260.30≥95% Pricing
AP137302-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylic acid288.3≥95% Pricing
AP137312-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid288.3≥95% Pricing
AP139713-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride309.75≥95% Pricing
AP139733-(5-Bromo-1-oxo-2-isoindolinyl)piperidine-2,6-dione323.14≥95% Pricing
AP139753-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione323.14≥95% Pricing
AP139723-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione323.14≥95% Pricing
AP139743-(7-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione323.14≥95% Pricing
AP139763-(5-iodo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione370.14≥95% Pricing
MZ1
AP14307ARV-771986.70≥95% Pricing
AP14308MZ11002.6≥95% Pricing
Pomalidomide
AP13277Pomalidomide273.2≥98% Pricing
Pomalidomide-PEG-Acid
AP12995Pomalidomide-PEG3-Acid477.47≥95% Pricing
AP12396Pomalidomide-PEG4-Acid521.52≥95% Pricing
AP13000Pomalidomide-PEG5-Acid565.58≥95% Pricing
Pomalidomide-PEG-Amine
AP13888Pomalidomide-PEG3-Amine HCl salt484.9≥95% Pricing
Pomalidomide-PEG-Azide
AP13278Pomalidomide 4-PEG3-Azide 474.5≥95% Pricing
AP12130Pomalidomide-PEG4-Azide518.53≥95% Pricing
AP13279Pomalidomide-PEG5-Azide590.6≥98% Pricing
AP13887Pomalidomide-PEG8-Azide694.7≥95% Pricing
Pomalidomide-PEG-Bromide
AP12997Pomalidomide-PEG3-Bromide512.36≥95% Pricing
Pomalidomide-PEG-NH-Boc
AP13828Pomalidomide-PEG3-NH-Boc548.6≥95% Pricing
Pomalidomide-PEG-Ph-NH2
AP13280Pomalidomide-PEG4-Ph-NH2540.6≥95% Pricing
THAL-SNS-032
AP14679THAL-SNS-032869.00≥95% Pricing
Thalidomide
AP13817Thalidomide258.2≥98% Pricing
AP139553-{5,7-dioxo-5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}piperidine-2,6-dione259.22≥95% Pricing
AP139565-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione273.24≥95% Pricing
AP121224-Hydroxy-thalidomide274.23≥95% Pricing
AP121294-Fluoro-thalidomide276.22≥95% Pricing
AP139572-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione276.22≥95% Pricing
AP139652-(2,6-Dioxopiperidin-3-yl)-5-ethynylisoindoline-1,3-dione282.25≥95% Pricing
AP139582-(2,6-Dioxopiperidin-3-Yl)-5,6-Difluoroisoindoline-1,3-Dione294.21≥95% Pricing
AP139642-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindoline-5-carboxylic acid302.24≥95% Pricing
AP139632-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid302.24≥95% Pricing
AP12123Thalidomide-Acid332.27≥95% Pricing
AP139615-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione337.12≥95% Pricing
AP139603-(4-Bromo-7-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione341.13≥95% Pricing
AP139662-Chloro-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide349.72≥95% Pricing
AP139622-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione384.13≥95% Pricing
AP139592-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride 396.8≥95% Pricing
Thalidomide-5-amine
AP13929Thalidomide-5-(C6-amine)393.87≥95% Pricing
AP13930Thalidomide-5-(PEG2-amine)432.4≥95% Pricing
AP13931Thalidomide-5-(PEG4-amine)520.5≥95% Pricing
Thalidomide-Acid
AP12123Thalidomide-Acid332.27≥95% Pricing
AP13477Thalidomide-5-(PEG2-acid)461.4≥95% Pricing
AP13478Thalidomide-5-(PEG4-acid)549.5≥95% Pricing
Thalidomide-O-amido-PEG-NHBoc
AP13027Thalidomide-O-amido-PEG2-NHBoc562.58≥95% Pricing
AP13029Thalidomide-O-amido-propoxy-PEG2-C3-NHBoc634.68≥95% Pricing
Thalidomide-O-PEG-Acid
AP14113Thalidomide-O-Hexyl-Acid402.40≥95% Pricing
AP13443Thalidomide-O-PEG2-Acid434.4≥98% Pricing
AP13444Thalidomide-O-PEG4-Acid522.5≥98% Pricing
AP13001Thalidomide-O-PEG5-Acid566.56≥95% Pricing
AP13445Thalidomide-O-PEG6-Acid610.6≥98% Pricing
Thalidomide-O-PEG-alcohol
AP13014Thalidomide-O-PEG3-alcohol406.39≥95% Pricing
Thalidomide-O-PEG-Amine
AP13119Thalidomide-O-amido-C4-amine402.4≥95% Pricing
AP13874Thalidomide-O-PEG2-Amine405.4≥95% Pricing
AP14112Thalidomide-O-C6-Amine HCl409.90≥95% Pricing
AP13004Thalidomide-O-PEG2-Amine HCl salt441.87≥95% Pricing
AP13015Thalidomide-O-PEG3-amine449.46≥95% Pricing
AP12124Thalidomide-O-PEG4-Amine493.51≥95% Pricing
AP13120Thalidomide-O-amido-C4-amine TFA Salt516.43≥95% Pricing
AP12384Thalidomide-O-PEG5-amine537.56≥ (95%) Pricing
AP13023Thalidomide-O-amido-C6-amine TFA salt544.48≥95% Pricing
AP13028Thalidomide-O-amido-C8-NHBoc558.63≥95% Pricing
AP13022Thalidomide-O-amido-C8-amine TFA salt572.54≥95% Pricing
AP13020Thalidomide-O-amido-PEG2-amine TFA salt576.48≥95% Pricing
AP12385Thalidomide-O-PEG6-amine581.62≥ (95%) Pricing
AP13024Thalidomide-O-amido-PEG3-amine TFA salt620.54≥95% Pricing
AP13026Thalidomide-O-amido-propoxy-PEG2-C3-amine TFA salt648.59≥95% Pricing
AP13025Thalidomide-O-amido-PEG4-amine TFA salt664.59≥95% Pricing
Thalidomide-O-PEG-Azide
AP15579Thalidomide-O-PEG2-azide431.41≥95% Pricing
AP11576Thalidomide-O-PEG4-Azide519.51≥95% Pricing
AP12125Thalidomide-O-amido-PEG4-azide576.56≥95% Pricing
Thalidomide-O-PEG-CH2-Ald
AP13013Thalidomide-O-PEG2-CH2-Ald404.38≥95% Pricing
Thalidomide-O-PEG-NHS ester
AP13384Thalidomide-O-PEG2-NHS ester531.5≥98% Pricing
AP12126Thalidomide-O-PEG4-NHS ester619.58≥95% Pricing
AP13385Thalidomide-O-PEG6-NHS ester707.7≥98% Pricing
Thalidomide-O-PEG-Propargyl
AP13003Thalidomide-O-PEG2-Propargyl400.39≥95% Pricing
AP13002Thalidomide-O-PEG3-Propargyl444.44≥95% Pricing
AP12334Thalidomide-O-PEG4-Propargyl488.49≥95% Pricing
AP12127Thalidomide-O-amido-PEG4-propargyl545.55≥95% Pricing
Thalidomide-O-PEG-t-butyl ester
AP12128Thalidomide-O-PEG4-t-butyl ester578.62≥95% Pricing
Thalidomide-O-PEG-Tosyl
AP13816Thalidomide-O-PEG5-Tosyl648.6≥98% Pricing
VH-298
AP14678VH-298523.70≥95% Pricing
VHL Ligand 1
AP12131VHL Ligand 1 HCl salt467.03≥95% Pricing

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    PROTAC: Changing How We Target Disease-Causing Proteins Overview: PROTACs (PROteolysis TArgeting Chimeras) are shaking up the field of drug development. Unlike traditional treatments that simply block harmful proteins, PROTACs remove them entirely. By using the body’s natural system to break down proteins, PROTACs offer new hope for treating cancers, neurodegenerative diseases, and autoimmune disorders.

    How PROTACs Work

    PROTACs use three main parts:
    • Target Ligand: This binds to the specific protein that needs to be broken down.
    • E3 Ligase Ligand: This connects to the E3 ubiquitin ligase, which tags the protein for destruction.
    • Linker: This holds the two ligands together, helping them bring the target protein and E3 ligase into contact.
    After the PROTAC links the target protein to the E3 ligase, the ligase adds a ubiquitin tag to the protein. This tag tells the cell to destroy the protein in the proteasome. Unlike inhibitors, PROTACs can keep working, breaking down many proteins with just one molecule.

    Key Benefits

    There are several reasons why PROTACs stand out:
    • Selective Degradation: PROTACs only break down the specific proteins causing disease, which reduces side effects.
    • Catalytic Action: They work over and over, degrading multiple proteins after a single binding event.
    • Expanded Targets: PROTACs can target proteins that were once thought to be "undruggable."

    Applications of PROTACs

    Cancer Treatment: PROTACs have shown success in targeting cancer-related proteins like androgen and estrogen receptors. For example, ARV-110 is being developed for prostate cancer, and ARV-471 targets breast cancer. Neurodegenerative Diseases: By breaking down harmful proteins, PROTACs show promise in treating diseases like Alzheimer’s and Parkinson’s. Autoimmune Disorders: PROTACs can target proteins that cause inflammation, which could lead to better treatments for autoimmune conditions.

    Leading PROTACs in Development

    • ARV-110 (Arvinas): Targets the androgen receptor in prostate cancer.
    • ARV-471 (Arvinas): Targets the estrogen receptor in breast cancer.
    • dBET1 (Dana-Farber): Breaks down BRD4, a protein linked to cancer.
    • CFT7455 (C4 Therapeutics): Targets proteins involved in multiple myeloma.
    • NX-2127 (Nurix Therapeutics): Breaks down BTK in B-cell cancers.

    Challenges

    There are still some challenges to overcome. First, PROTACs need precise linker design to work well. Also, delivering them to the right tissues in the body can be difficult. However, ongoing clinical trials are showing good progress, and more PROTACs are moving through development.

    Conclusion

    PROTACs are changing the way we treat diseases by breaking down harmful proteins. This approach offers a more effective and targeted treatment option for cancer, neurodegenerative diseases, and autoimmune disorders. With many PROTACs showing promise in clinical trials, they are set to make a big impact on modern medicine.