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PC cleavable linkers are a type of small molecule linker used in drug discovery and development. These linkers contain a cleavable bond that can be selectively broken in the presence of a specific enzyme, known as a protease. Proteases are enzymes that break down proteins, and they are present in a variety of biological systems, including in certain types of cancer cells.

PC cleavable linkers are used to create targeted drugs that can be delivered specifically to cancer cells, while minimizing damage to healthy cells. When a PC cleavable linker is attached to a drug molecule, it can be designed to be cleaved only by a specific protease that is overexpressed in cancer cells. This allows the drug to be released selectively in cancer cells, where it can exert its therapeutic effect.

There are several different types of PC cleavable linkers, including those that are cleaved by caspases, matrix metalloproteinases, and other proteases. The choice of linker will depend on the specific protease that is present in the target tissue, as well as on the properties of the drug molecule that is being delivered.

Cat# Name Structure M.W. Purity Pricing
AP14069PC Alkyne Agarose55.04≥95% Pricing
AP14070PC Azide Agarose100.07≥95% Pricing
AP14285PC SPDP467.60≥95% Pricing
AP11188PC Mal-NHS carbonate ester562.49≥95% Pricing
AP11186PC SPDP-NHS carbonate ester608.64≥95% Pricing
AP12598PC Azido-NHS Ester640.60≥95% Pricing
AP12599PC Alkyne-NHS Ester653.64≥95% Pricing
AP11187PC Alkyne-PEG4-NHS carbonate ester653.64≥95% Pricing
AP11061PC Biotin-PEG3-alkyne780.89≥95% Pricing
AP11189PC Methyltetrazine-PEG4-NHS carbonate ester785.76≥95% Pricing
AP11086PC-Biotin-PEG4-NHS carbonate810.87≥95% Pricing
AP11052PC Biotin-PEG3-azide825.94≥95% Pricing
AP12610PC Biotin-NHS ester840.89≥90% Pricing
AP11085PC Biotin-PEG3-NHS carbonate ester840.9≥95% Pricing
AP11084PC-Biotin-PEG4-PEG3-azide914.04≥95% Pricing
AP11062PC-Biotin-PEG4-PEG4-alkyne927.08≥95% Pricing
AP12701PC DBCO-NHS Ester945.98≥95% Pricing
AP11190PC Azido-PEG11-NHS carbonate ester993.03≥95% Pricing
AP11071PC DBCO-PEG3-biotin1002.15≥95% Pricing

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