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Acid reactive linkers are a class of chemical compounds that have gained significant interest in recent years due to their diverse applications in various fields, including drug discovery and bioconjugation. These linkers are designed to be stable under physiological conditions, but reactive towards acidic environments, such as those found in endosomes and lysosomes. This reactivity allows for controlled release of the attached cargo, making them ideal for drug delivery applications.

One of the most commonly used acid reactive linkers is hydrazone, which is formed between an aldehyde or ketone group and a hydrazide or hydrazine derivative. Other acid reactive linkers include oxime and imine, which are also formed through the reaction between carbonyl groups and amine or hydroxyl groups.

acid reactive linkers provide a valuable tool for the design of targeted drug delivery systems, imaging agents, and biomaterials. The ability to precisely control the release of therapeutic or diagnostic agents is essential for achieving optimal efficacy and minimizing side effects.

Acid reactive Linkers

PEG Applications

ADC Conjugation
Click Chemistry
Dye Labeling
Drug Delivery

Top 10 selling High purity Acid reactive Linkers
Cat# Name Structure M.W. Purity Pricing
AP10452Amino-PEG24-t-butyl ester1202.46≥95% Pricing
AP10215Amino-PEG6-alcohol281.35≥95% Pricing
AP10216Amino-PEG8-alcohol369.45≥95% Pricing
AP12138Amino-PEG3-acid221.25≥95% Pricing
AP12141Amino-PEG10-acid529.62≥95% Pricing
AP12142Amino-PEG12-acid617.73≥95% Pricing
AP12164Amino-PEG10-alcohol457.56≥95% Pricing
AP12166Amino-PEG24-alcohol1074.3≥95% Pricing
AP12168Amino-PEG1-amine104.15≥95% Pricing
AP12170Amino-PEG3-amine192.26≥95% Pricing

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