Folate (Folic Acid) PEG Linkers are PEG reagents with folic acid functionality. The folate receptor is a membrane-bound protein with high affinity for folate. This receptor acts as a receptor-mediated folate transport system into cancer cells and cells associated with inflammation (eg, macrophages). As an essential component of cellular metabolism in DNA and protein synthesis, folic acid is considered necessary to maintain elevated metabolic processes. Unlike most normal cells in the body that have little affinity for folate, cancer cells have highly expressed folate receptor alpha. Because of these properties, folic acid (folate) can selectively bind to folate receptors in a wide range of cancer tissues, such as ovarian cancer, lung cancer, and more. Folic acid-polyPEG can be used to design nanoparticle-based targeted cancer therapy via the folate receptor, thereby minimizing nonspecific uptake in normal cells.
AxisPharm is the world’s leading supplier of folate-related linkers for cross-linking technology. We have the largest collection of stocked folate PEG linkers to facilitate folate receptor related research.