DBCO-PEG4-Val-Cit-PAB-PNP CAS:2226472-28-0 is a multifunctional linker molecule consisting of a DBCO moiety, a PEG4 spacer, a Val-Cit dipeptide, a PAB group, and a PNP handle. The DBCO moiety enables click chemistry reactions, while the PEG4 spacer imparts water solubility and flexibility. The Val-Cit dipeptide functions as a protease-cleavable site, and the PAB and PNP groups serve as additional conjugation handles for bioactive molecules.
In pharmaceutical research and development, DBCO-PEG4-Val-Cit-PAB-PNP is employed as a versatile DBCO linker for constructing antibody-drug conjugates (ADCs). Its unique structure enables the conjugation of cytotoxic drugs to antibodies, facilitating targeted drug delivery to specific cancer cells. The protease-cleavable Val-Cit dipeptide allows for controlled drug release, while the PEG4 spacer and click chemistry capability streamline ADC development, leading to novel, effective cancer therapies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.