Methyltetrazine-PEG4-DBCO is a multifunctional linker comprising two distinct chemical moieties: a methyltetrazine group that enables rapid bioorthogonal ligation via inverse electron-demand Diels-Alder reactions, and a dibenzocyclooctyne (DBCO) group for copper-free click chemistry. The PEG4 spacer imparts water solubility and reduces steric hindrance, thereby enhancing the molecule’s overall performance.
Introduction to the Application:
In pharmaceutical research and development, Methyltetrazine-PEG4-DBCO serves as an invaluable tool for the site-specific conjugation of biomolecules, including proteins, nucleic acids, and small molecules. Its dual-reactive nature enables the efficient construction of complex bioconjugates, facilitating the development of targeted drug delivery systems, bioorthogonal imaging probes, and advanced diagnostic tools that promise to revolutionize modern therapeutics and improve patient outcomes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.