DBCO-PEG6-acid is a specialized compound in the field of bioconjugation, featuring a carboxylic acid functional group (-COOH) and a dibenzocyclooctyne (DBCO) group. The DBCO group is particularly notable for its ability to react with azide functional groups through a copper-free click chemistry reaction, a key technique in modern bioconjugation methodologies.
As a popular building block for DBCO derivatization, DBCO-PEG6-acid’s acid group can react with amines to form amide bonds under coupling conditions. This reaction typically occurs in the presence of activators such as EDC, DCC, and HATU. Moreover, the DBCO component of the molecule is primed to readily react with azide-bearing biomolecules through a copper-free click reaction, which occurs instantly and yields high efficiency. This reaction is a cornerstone of DBCO click chemistry, known for its specificity and rapidity.
In the realm of pharmaceutical research and development, DBCO-PEG6-acid serves as a versatile and valuable tool. It offers unique opportunities for the design and optimization of drug delivery systems and diagnostic tools. The compound’s ability to facilitate targeted and efficient conjugation makes it a sought-after component in the development of innovative therapeutics and diagnostics. Researchers and developers seeking DBCO-based compounds for their projects can explore a wide range of options, including DBCO linkers and DBCO NHS, at AxisPharm, catering to diverse scientific needs.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.