t-Boc-N-Amido-PEG4-acid-amine DBCO is a PEG linker with a DBCO group and a Boc-amine group. DBCO readily undergoes copper free click chemistry with azide bearing biomolecules and form a stable triazole hinge. The amine group, after mild acid de-Boc protection, can couple with carboxylic acid, activated ester group to form amide bond. The hydrophilic PEG spacer arm improves water solubility.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.