DSPE-DBCO (Dibenzocyclooctyne-Functionalized DSPE) is a click-reactive phospholipid featuring a hydrophobic DSPE lipid anchor and DBCO functionality, while the strained cyclooctyne group reacts with azides through copper-free strain-promoted azide–alkyne cycloaddition (SPAAC).
Key Features and Benefits
- DBCO-Functionalized Phospholipid: DSPE-DBCO provides a reactive dibenzocyclooctyne group for copper-free click chemistry.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into compatible lipid membranes and assemblies.
- DBCO Functionality: The strained cyclooctyne group specifically provides selective reactivity toward compatible azide-functionalized molecules.
- Copper-Free Click Chemistry: DBCO supports SPAAC reactions with azides without requiring a copper catalyst.
- Stable Conjugation: SPAAC forms a stable covalent triazole linkage between DBCO and azide-functionalized molecules.
- Amphiphilic Character: The DSPE structure supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Surface Functionalization: DSPE-DBCO provides click-reactive functionality at lipid interfaces for subsequent modification.
- Functional Lipid Platform: The combination of a DSPE anchor and DBCO specifically supports diverse click chemistry and biomaterial applications.
Applications
- SPAAC Click Chemistry: DSPE-DBCO (Dibenzocyclooctyne-Functionalized DSPE) supports copper-free conjugation with compatible azide-containing molecules.
- Bioconjugation: Enables covalent attachment of azide-functionalized peptides, proteins, probes, and other biomolecules.
- Ligand Conjugation: Supports attachment of azide-containing ligands through copper-free click chemistry.
- Liposome Functionalization: Enables incorporation of DBCO-functionalized phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a click-reactive lipid component for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports azide-DBCO conjugation on compatible lipid-containing nanoparticles.
- Surface Modification: Provides DBCO functionality for copper-free modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of click-functionalized lipid conjugates, assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-DBCO (Dibenzocyclooctyne-Functionalized DSPE) combines a hydrophobic DSPE lipid anchor with click-reactive DBCO functionality and specifically provides a versatile platform for SPAAC, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
