DBCO-PEG8-DBCO linker homofuncational DBCO crosslinker, exemplifying the innovative applications of DBCO click chemistry. It can undergo sequential copper free click chemistry with azide-tagged biomolecules to form stable triazole linkages separated by the hydrophilic PEG spacer, which provides added aqueous solubility and rotational flexibility.
DBCO-PEG8-DBCO contains two Dibenzylcyclooctyne (DBCO) functional groups on each end of an eight-unit PEG chain. The DBCO functional group is known for its ability to react with azide functional groups through the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction.
DBCO-PEG8-DBCO has been widely utilized in the development of novel drug delivery systems, such as antibody-drug conjugates (ADCs), which are designed to selectively deliver cytotoxic agents to cancer cells. The DBCO functional groups of DBCO-PEG8-DBCO can be used to attach the drug molecules to the PEG chain through the CuAAC reaction, resulting in stable and efficient ADCs with enhanced targeting capabilities and reduced toxicity.
For researchers and scientists in the field of pharmaceuticals and bioconjugation, understanding the intricacies of DBCO-based chemistry, including the usage of DBCO NHS, is crucial for the development of more effective therapeutic solutions. AxisPharm provides a wide range of DBCO-related compounds, including various DBCO linkers, which are essential for innovative research and development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.