Revolutionize Your Research with TCO-Tetrazine Ligation
TCO PEG Linkers are bioorthogonal agents for tetrazine. The cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for bioconjugation, molecular imaging and cell-based diagnostics.
The chemoselective TCO–Tz ligation pair possess ultrafast kinetics unmatched by any other bioorthogonal ligation pair.
Hydrophobic TCOs can be masked to lose activity by hydrophobic interactions with mAb. However, pegylating TCOs with polyethylene glycol (PEG) spacers help minimize the interaction and improve the activity. In addition, PEG spacers help reduce aggregation of mAb conjugates and provide increased water solubility, reduced immunogenicity, improved pharmacokinetics and pharmacodynamics properties.
Why Choose Our TCO Linker?
1. Exceptional Reactivity
Our TCO Linker offers exceptional reactivity with tetrazine compounds, facilitating rapid and efficient click chemistry reactions. Experience cleaner reactions and higher yields with minimal side products.
2. High Purity
Manufactured to the highest standards, our TCO Linker ensures high purity and consistent quality, giving you confidence in your results and reproducibility.
3. Versatile Applications
Ideal for a wide range of applications including:
- Chemical Synthesis: Streamline the synthesis of complex molecules with ease.
- Bio-Conjugation: Achieve precise labeling and tagging for biomedical research and therapeutic development.
- Material Science: Enhance the development of innovative materials with advanced cross-linking techniques.
4. Easy to Use
Designed with simplicity in mind, our TCO Linker integrates seamlessly into your existing workflows. With straightforward protocols and a comprehensive collection of TCO Linkers, you can easily incorporate it into your research and production processes.
Product Features
- Chemical Structure: Optimized for superior performance and high specificity.
- Purity: Highest purity possible to suit your needs.
- Packaging Options: Available in multiple sizes to accommodate both small-scale experiments and large-scale production.
Applications and Benefits
- Enhanced Reaction Efficiency: Reduce reaction times and improve yields.
- Improved Precision: Achieve highly specific and reliable conjugations.
- Broad Compatibility: Suitable for a wide range of chemical and biological systems.
