ADC Linkers

Antibody–drug conjugates (ADCs) consist of a desirable monoclonal antibody, a potent cytotoxic drug and an appropriate linker. They have gain popularity as an innovative therapeutic approach for targeted cancer treatments. ADC linkers play key roles in determining the pharmacokinetic properties, therapeutic index, selectivity and the overall success of the ADC.

A properly selected linker helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers play critical roles in ADCs’ stability during the preparation, storage and ADC systemic circulation. The design of linkers for ADCs is challenging as it has to meet stringent criteria of extracellular stability and intracellular release. Intracellular acid and reducing environment, cathepsin enzymatic hydrolysis environment can catalyze or activate the cleavage and release of the payload.

AxisPharm develops a broad range of Linkers and provide custom linker synthesis. Our current product catalog covers click chemistry tools such as DBCO, tetrazine, TCO, BCN and cycloprpene etc., biotin linkers, PEG linkers, peptide linkers, glucuronide linkers, photo cleavable linkers, dye probe linkers and folic acid peg linkers.

As a customer-oriented contract research company, we offer flexible ADC Linker product kits and Bioconjugation services with competitive price.

ref: “Linkers Having a Crucial Role in Antibody–Drug Conjugates”, Int J Mol Sci. 2016 Apr; 17(4): 561.

ADC Linkers

ADC Linkers

Antibody–drug conjugates (ADCs) consist of a desirable monoclonal antibody, a potent cytotoxic drug and an appropriate linker. They have gain popularity as an innovative therapeutic approach for targeted cancer treatments. ADC linkers play key roles in determining the pharmacokinetic properties, therapeutic index, selectivity and the overall success of the ADC.

A properly selected linker helps the antibody to selectively deliver the cytotoxic drug to tumor cells and accurately releases the cytotoxic drug at tumor sites. In addition to conjugation, the linkers play critical roles in ADCs’ stability during the preparation, storage and ADC systemic circulation. The design of linkers for ADCs is challenging as it has to meet stringent criteria of extracellular stability and intracellular release. Intracellular acid and reducing environment, cathepsin enzymatic hydrolysis environment can catalyze or activate the cleavage and release of the payload.

AxisPharm develops a broad range of Linkers and provide custom linker synthesis. Our current product catalog covers click chemistry tools such as DBCO, tetrazine, TCO, BCN and cycloprpene etc., biotin linkers, PEG linkers, peptide linkers, glucuronide linkers, photo cleavable linkers, dye probe linkers and folic acid peg linkers.

As a customer-oriented contract research company, we offer flexible ADC Linker product kits and Bioconjugation services with competitive price.

ref: “Linkers Having a Crucial Role in Antibody–Drug Conjugates”, Int J Mol Sci. 2016 Apr; 17(4): 561.

Catalog No. Name Structure M.W. Purity Pricing
BCN Linkers
AP10548 endo-BCN-NHS endo-BCN-NHS 291.3 95% Pricing

AP10548

endo-BCN-NHS
Unit Price(USD) Quantity
50mg $185.00
100mg $345.00
AP10584 Endo-BCN-PEG4-NHS ester Endo-BCN-PEG4-NHS ester 538.59 95% Pricing

AP10584

Endo-BCN-PEG4-NHS ester
Unit Price(USD) Quantity
50mg $340.00
100mg $495.00
250mg $1,100.00
AP10731 endo-BCN-PEG4-PFP ester endo-BCN-PEG4-PFP ester 607.56 95% Pricing

AP10731

endo-BCN-PEG4-PFP ester
Unit Price(USD) Quantity
50 mg $450.00
100 mg $780.00
250 mg $1,450.00
AP10754 endo-BCN-PEG3-Biotin endo-BCN-PEG3-Biotin 550.71 95% Pricing

AP10754

endo-BCN-PEG3-Biotin
Unit Price(USD) Quantity
25mg $780.00
50mg $1,280.00
100mg $1,980.00
AP12383 (1a,8a,9b)-Bicyclo[6.1.0]non-4-ene-9-methanol (1a,8a,9b)-Bicyclo[6.1.0]non-4-ene-9-methanol 152.24 95% Pricing

AP12383

(1a,8a,9b)-Bicyclo[6.1.0]non-4-ene-9-methanol
Unit Price(USD) Quantity
250mg $454.00
500mg $680.00
1g $980.00
AP11437 (2-pyridyldithio)-PEG4-alcohol (2-pyridyldithio)-PEG4-alcohol 319.43 95% Pricing

AP11437

(2-pyridyldithio)-PEG4-alcohol
Unit Price(USD) Quantity
100mg $320.00
250mg $480.00
500mg $720.00
AP11438 (2-pyridyldithio)-PEG4-propargyl (2-pyridyldithio)-PEG4-propargyl 357.48 95% Pricing

AP11438

(2-pyridyldithio)-PEG4-propargyl
Unit Price(USD) Quantity
100mg $320.00
250mg $540.00
500mg $810.00
AP11265 (4-methoxyphenyl)diphenylmethylamino-PEG7 (4-methoxyphenyl)diphenylmethylamino-PEG7 597.75 95% Pricing

AP11265

(4-methoxyphenyl)diphenylmethylamino-PEG7
Unit Price(USD) Quantity
250mg $540.00
500mg $780.00
1g $1,200.00
AP10763 (R)-2,6-Bis-(m-PEG4)-amidohexanoic acid (R)-2,6-Bis-(m-PEG4)-amidohexanoic acid 582.69 95% Pricing

AP10763

(R)-2,6-Bis-(m-PEG4)-amidohexanoic acid
Unit Price(USD) Quantity
250mg $580.00
500mg $890.00
1g $1,335.00
AP12132 (S,R. S)-AHPC-PEG2-acid (S,R. S)-AHPC-PEG2-acid 618.75 95% Pricing

AP12132

(S,R. S)-AHPC-PEG2-acid
Unit Price(USD) Quantity
100mg $540.00
250mg $960.00
500mg $1,900.00
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