ADC Conjugation Service at AxisPharm
Conjugation is the process of linking molecules/polymers or biomolecules/biopolymers together by covalent bonds. Conjugation can enhance drug efficacy by improving pharmacokinetic and pharmacodynamic properties and by reducing plasma protein binding. For instance, introducing polyethylene glyco (PEG) or polysaccharide reduces toxicity and improves solubility and stability. At AxisPharm, we offer affordable and high quality custom ADC conjugation service using our combinatorial approach with various payloads, linkers, and conjugation methods.
Polymer-drug conjugates with target specific peptide ligands can provide a solution for selective and targeted drug delivery.
Our conjugation service delivers affordable and high quality custom ADCs, using combinations of payloads, linkers, and conjugation methods. Service includes a comprehensive ADC report with full characterizing specifications. We offer the following ADC conjugation service:
- Protein-drug Conjugation
- Fluorophore Conjugation
- Biotin conjugation
- Antibody-drug conjugate (ADC)
- Polymer–drug conjugation
- Polymer-drug-target ligand conjugation
We use various strategies for ADC conjugation service, such as:
- Cysteine-based conjugation
- Lysine-based conjugation
- Thio-engineered antibody
- Carbohydrate-based conjugation
- Unnatural amino acids-based conjugation
Analytical – AxisPharm has the analytical tools and experience that are critical for this field. We are equipped with sophisticated mass spectrometers for small and large molecules to analyze and quantify protein, antibody and their conjugates.
Synthetic Chemistry and Biology Expertise – AxisPharm has a large collection of ADC linker, such as PEG linker, Peptide Linker, Sugar Liner, Dye Probe in stock and has extensive experience in synthesis, purification and characterization of both small and large molecules to support bioconjugation R&D.