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Cleavable PEG Reagents play a crucial role in the success of antibody-drug conjugates. It determines the fate of the cytotoxic drug in the biological system. In order to make the ADC effective, it requires the Cleavable reagents to be stable enough in the blood circulation for a substantial amount of time to avoid side toxicity and to allow ADC to reach the target. It also requires the reagents to be labile so that they efficiently release corresponding payload in the tumor environment.

AxisPharm provides functionalized cleavable PEGs with disulfide bonds or photocleavable bonds. Different kinds of antibody-drug conjugates Reagents may be available by custom synthesis.

Cat# Name Structure M.W. Purity Pricing
-S-S- Cleavable
AP11154Aminoethyl-SS-ethylamine152.27≥95% Pricing
AP11151Aminoethyl-SS-ethylalcohol153.26≥95% Pricing
AP11158Azidoethyl-SS-ethylamine178.27≥95% Pricing
AP11005Azidoethyl-SS-ethylalcohol179.26≥95% Pricing
AP11152Aminoethyl-SS-propionic acid181.27≥95% Pricing
AP11162Propargyl-PEG1-SS-alcohol192.29≥95% Pricing
AP11159Azidoethyl-SS-ethylazide204.27≥95% Pricing
AP11156Azidoethyl-SS-propionic acid207.27≥95% Pricing
AP11165Propargyl-PEG1-SS-PEG1-propargyl230.34≥95% Pricing
AP11178THP-SS-alcohol238.36≥95% Pricing
AP13724(S)-2-amino-4-(2-(pyridin-2-yl)disulfanyl)butanoic acid244.3≥95% Pricing
AP11155t-Boc-Cystamine252.39≥95% Pricing
AP11163Propargyl-PEG1-SS-PEG1-acid264.35≥95% Pricing
AP11006N-Boc-Aminoethane-SS-acetic acid267.36≥95% Pricing
AP11172Boc-aminooxy-ethyl-SS-propanol269.37≥95% Pricing
AP11171Boc-NH-ethyl-SS-propionic acid281.39≥95% Pricing
AP11001Azido-SS-PEG2-acid295.37≥95% Pricing
AP11157Azidoethyl-SS-propionic NHS ester304.34≥95% Pricing
AP111812-hydroxyethyl disulfide mono-Tosylate308.43≥95% Pricing
AP11166Propargyl-PEG1-SS-PEG1-t-butyl ester320.46≥95% Pricing
AP11175Mal-NH-ethyl-SS-propionic acid332.39≥95% Pricing
AP11161Azidoethyl-PEG2-t-Butyl ester351.48≥95% Pricing
AP11179THP-SS-PEG1-t-butyl ester366.53≥95% Pricing
AP14240Trifluoroacetamidoethyl-SS-propionic NHS ester374.40≥95% Pricing
AP11007Amino-ethyl-SS-PEG3-NHBoc384.55≥95% Pricing
AP11167Acid-PEG2-SS-PEG2-acid386.47≥95% Pricing
AP11180THP-SS-PEG1-Tos392.54≥95% Pricing
AP134814-Azide-TFP-Amide-SS-propionic acid398.4≥98% Pricing
AP11173Fmoc-NH-ethyl-SS-propionic acid403.51≥95% Pricing
AP13585Biotin-SS-Amine HCl Salt415≥98% Pricing
AP11176Hydroxy-PEG3-SS-PEG3-alcohol418.56≥95% Pricing
AP11164Propargyl-PEG1-SS-PEG1-PFP ester430.4≥95% Pricing
AP13833NHS-PEG1-SS-PEG1-NHS436.4≥95% Pricing
AP11182Bis-Tos-(2-hydroxyethyl disulfide)462.61≥95% Pricing
AP11160Azido-PEG3-SS-PEG3-azide468.59≥95% Pricing
AP14196DBCO-S-S-acid468.60≥95% Pricing
AP11168Acid-PEG3-SS-PEG3-acid474.58≥95% Pricing
AP11174Fmoc-NH-ethyl-SS-propionic NHS ester500.58≥95% Pricing
AP13873Azido-Phenyl-Amido-S-S-Sulfo-NHS525.50≥95% Pricing
AP11169Acid-PEG4-SS-PEG4-acid562.69≥95% Pricing
AP11183Biotin-bisamido-SS-NHS575.71≥95% Pricing
AP11185Sulfo-NThiol-SS-biotin606.67≥95% Pricing
AP11177m-PEG6-SS-PEG6-methyl622.83≥95% Pricing
AP11083Biotin-PEG3-SS-azide692.91≥95% Pricing
AP11153Amino-SS-PEG12-acid709.9≥95% Pricing
AP11170Acid-PEG6-SS-PEG6-acid738.9≥95% Pricing
AP13557Biotin-PEG4-S-S-NHS751.9≥98% Pricing
AP11068DBCO-S-S-PEG3-biotin869.12≥95% Pricing
AP13480Biotin-PEG4-S-S-acid654.9≥98% Pricing
Cleavable Peptide
AP11194Azido-PEG3-Val-Cit-PAB-OH608.7≥95% Pricing
AP10695Mal-PEG2-Val-Cit-PAB-OH618.68≥95% Pricing
AP11195Azido-PEG4-Val-Cit-PAB-OH652.75≥95% Pricing
AP11197BCN-PEG3-Val-Cit653.77≥95% Pricing
AP11192Mal-amido-PEG2-Val-Cit-PAB-OH689.77≥95% Pricing
AP10696Mal-PEG4-Val-Cit-PAB-OH706.78≥95% Pricing
AP11196Azido-PEG3-Val-Cit-PAB-PNP773.8≥95% Pricing
AP11198BCN-PEG3-VC-PFP Ester819.82≥95% Pricing
AP11193Mal-amido-PEG2-Val-Cit-PAB-PNP854.87≥95% Pricing
AP11191Mal-PEG4-Val-Cit-PAB-PNP871.9≥95% Pricing
AP13223TCO-PEG4-Val-Cit-PAB-PNP 944.1≥98% Pricing
AP13199DBCO-PEG4-Val-Cit-PAB-PNP1079.2≥98% Pricing
AP13204DBCO-PEG8-Val-Cit-PAB-PNP1255.4≥95% Pricing
AP13201DBCO-PEG4-Val-Cit-PAB-MMAE1658.1≥98% Pricing
Dde Cleavable Linkers
AP14068Dde Alkyne Agarose55.04≥95% Pricing
AP13862Dde Azide Agarose142.12≥95% Pricing
AP11058Dde Biotin-PEG4-alkyne650.83≥95% Pricing
AP12592Dde Biotin Azide695.88≥95% Pricing
AP11048Dde Biotin-PEG4-azide695.88≥95% Pricing
AP11049Dde Biotin-PEG4-Picolyl azide815.99≥95% Pricing
AP12676Dde Biotin Azide Plus834.05≥95% Pricing
AP11070Dde Biotin-PEG4-DBCO872.09≥95% Pricing
AP12636Dde TAMRA Biotin Azide1425.71≥95% Pricing
AP12637Dde TAMRA Biotin Alkyne1438.74≥95% Pricing
diazo biotin probes
AP13729BB1-acid467.56≥98% Pricing
AP14184BB1-NHS ester564.6≥95% Pricing
AP11050Diazo Biotin-PEG3-azide711.84≥95% Pricing
AP11059Diazo Biotin-PEG3-alkyne795.95≥95% Pricing
AP14193Diazo-PEG3-methyltetrazine854≥95% Pricing
AP11067Diazo Biotin-PEG3-DBCO973.16≥95% Pricing
Disulfide Linkers
AP11154Aminoethyl-SS-ethylamine152.27≥95% Pricing
AP11151Aminoethyl-SS-ethylalcohol153.26≥95% Pricing
AP11158Azidoethyl-SS-ethylamine178.27≥95% Pricing
AP11005Azidoethyl-SS-ethylalcohol179.26≥95% Pricing
AP11152Aminoethyl-SS-propionic acid181.27≥95% Pricing
AP13848Disulfide Azide Agarose188.28≥95% Pricing
AP11156Azidoethyl-SS-propionic acid207.27≥95% Pricing
AP11001Azido-SS-PEG2-acid295.37≥95% Pricing
AP11157Azidoethyl-SS-propionic NHS ester304.34≥95% Pricing
AP111812-hydroxyethyl disulfide mono-Tosylate308.43≥95% Pricing
AP137213-[[2-[(4-azidobenzoyl)amino]ethyl]dithio]propanoicacid 326.4≥96% Pricing
AP13833NHS-PEG1-SS-PEG1-NHS436.4≥95% Pricing
AP135514-Azide-TFP-Amide-PEG4-acid482.4≥98% Pricing
AP11184NThiol-SS-biotin504.64≥95% Pricing
AP11183Biotin-bisamido-SS-NHS575.71≥95% Pricing
AP11185Sulfo-NThiol-SS-biotin606.67≥95% Pricing
AP13847Disulfide Biotin Alkyne647.87≥95% Pricing
AP13846Disulfide Biotin Azide692.91≥95% Pricing
AP11153Amino-SS-PEG12-acid709.9≥95% Pricing
AP13845Disulfide Biotin DBCO869.12≥95% Pricing
PC Cleavable
AP14069PC Alkyne Agarose55.04≥95% Pricing
AP14070PC Azide Agarose100.07≥95% Pricing
AP14285PC SPDP467.60≥95% Pricing
AP11188PC Mal-NHS carbonate ester562.49≥95% Pricing
AP11186PC SPDP-NHS carbonate ester608.64≥95% Pricing
AP12598PC Azido-NHS Ester640.60≥95% Pricing
AP12599PC Alkyne-NHS Ester653.64≥95% Pricing
AP11187PC Alkyne-PEG4-NHS carbonate ester653.64≥95% Pricing
AP11061PC Biotin-PEG3-alkyne780.89≥95% Pricing
AP11189PC Methyltetrazine-PEG4-NHS carbonate ester785.76≥95% Pricing
AP11086PC-Biotin-PEG4-NHS carbonate810.87≥95% Pricing
AP11052PC Biotin-PEG3-azide825.94≥95% Pricing
AP12610PC Biotin-NHS ester840.89≥90% Pricing
AP11085PC Biotin-PEG3-NHS carbonate ester840.9≥95% Pricing
AP11084PC-Biotin-PEG4-PEG3-azide914.04≥95% Pricing
AP11062PC-Biotin-PEG4-PEG4-alkyne927.08≥95% Pricing
AP12701PC DBCO-NHS Ester945.98≥95% Pricing
AP11190PC Azido-PEG11-NHS carbonate ester993.03≥95% Pricing
AP11071PC DBCO-PEG3-biotin1002.15≥95% Pricing
Photocleavable Biotin
AP13832PC-Biotin-PEG4669.8≥95% Pricing
AP11052PC Biotin-PEG3-azide825.94≥95% Pricing
AP12610PC Biotin-NHS ester840.89≥90% Pricing
AP11062PC-Biotin-PEG4-PEG4-alkyne927.08≥95% Pricing
β-Glucuronide Linkers
AP10974β-tetraacetylglucopyranoside-glycol392.36≥95% Pricing
AP10975β-tetraacetylglucopyranoside-glycerol422.38≥95% Pricing
AP10154β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate455.41≥95% Pricing
AP10976β-D-tetraacetylgalactopyranoside-PEG2-azide461.42≥95% Pricing
AP101524-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate483.38≥95% Pricing
AP10977β-D-tetraacetylgalactopyranoside-PEG3-azide505.48≥95% Pricing
AP10901β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine748.73≥95% Pricing
AP10153(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate913.83≥95% Pricing

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