Bromo PEG linkers are PEG derivatives featuring a terminal bromide group on one end and another functional group on the opposite end. The bromide (Br) acts as an excellent leaving group, facilitating nucleophilic substitution reactions, particularly forming sulfide bonds with thiol moieties on biomolecules for bioconjugation.
AxisPharm offers a range of high purity Bromo-PEG reagents with different linker lengths. Client-specific PEG Reagents may be available by custom synthesis. Fast shipping．
Bromo PEG
Bromo PEG Linkers are versatile chemical linkers containing a bromo group attached to a polyethylene glycol (PEG) chain. These linkers are widely used in bioconjugation, drug delivery, and surface modification due to their unique properties.
Key Features:
- Reactivity: The bromo group allows for efficient nucleophilic substitution reactions, enabling easy attachment to amines, thiols, or other functional groups on biomolecules and surfaces.
- PEG Chain Benefits: The PEG chain improves water solubility, reduces non-specific binding, and provides flexibility, making these linkers ideal for biological applications.
- Bioconjugation: Bromo PEG linkers are commonly used to connect proteins, peptides, or drugs to other molecules or surfaces, enhancing stability and solubility in biomedical applications.
- Drug Delivery: These linkers are used to attach therapeutic agents to targeting molecules, enhancing drug solubility, circulation time, and targeted delivery.
- Surface Modification: Bromo PEG linkers are employed to modify surfaces of nanoparticles, polymers, and other materials, providing biocompatibility and preventing protein adsorption.