DBCO-PEG6-DBCO contains two terminal azide-reactive DBCO (dibenzocyclooctyne) functional groups, separated by a PEG6 spacer.The DBCO functional group, a key element in DBCO click chemistry, is renowned for its high reactivity towards azide groups. This feature is fundamental in bioorthogonal chemistry, allowing for efficient and specific conjugation processes.
DBCO-PEG6-DBCO has been extensively utilized in the development of novel drug delivery systems, such as antibody-drug conjugates (ADCs) and imaging probes. Its unique chemical properties allow for the selective conjugation of therapeutic agents or imaging probes to biomolecules, such as antibodies, through click chemistry reactions. The resulting conjugates exhibit enhanced stability, increased selectivity, and reduced immunogenicity, leading to improved therapeutic efficacy and diagnostic accuracy.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.