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Thiol Reactive Linkers are used in ADC conjugation to target thiol group on biomolecules. Maleimide, acrylamide, vinyl sulfone, bromide and tosylated linkers are some of the most useful thiol reactive agents for bioconjugation. The maleimide linkers allow selective labeling of sulfhydryl groups such as cysteine residues in proteins and pepties, and oligonucleotides. Functionalized maleimide linkers with PEG spacer of different length offers researchers flexibility to fine tune their conjugation applications.

Besides amine-reactive compounds, thiol or sulfhydryls (–SH) reactive linkers are the most common crosslinkers for protein and other bioconjugations. Thiols exist in proteins’ side-chain of cysteine (Cys, C) amino acids. They often exist as disulfide bonds (–S–S–) within or between polypeptide chains as the basis of native tertiary or quaternary protein structure. Only the free or reduced sulfhydryl groups (–SH) are available for reaction with thiol-reactive compounds.

Thiol reactive Linkers
  • Bromo PEG
  • Cleavable PEG
  • PEG Maleimide
  • PEG Tosylate
Cat# Name Structure M.W. Purity Pricing
Top selling High purity Thiol reactive Linkers
AP10975β-tetraacetylglucopyranoside-glycerol422.38≥95% Pricing
AP10696Mal-PEG4-Val-Cit-PAB-OH706.78≥95% Pricing
AP11163Propargyl-PEG1-SS-PEG1-acid264.35≥95% Pricing
AP11166Propargyl-PEG1-SS-PEG1-t-butyl ester320.46≥95% Pricing
AP10901β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine748.73≥95% Pricing
AP11190PC Azido-PEG11-NHS carbonate ester993.03≥95% Pricing
AP11005Azidoethyl-SS-ethylalcohol179.26≥95% Pricing
AP11067Diazo Biotin-PEG3-DBCO973.16≥95% Pricing
AP11059Diazo Biotin-PEG3-alkyne795.95≥95% Pricing
AP11049Dde Biotin-PEG4-Picolyl azide815.99≥95% Pricing

PEG Applications

ADC Conjugation
Click Chemistry
Dye Labeling
Drug Delivery

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