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Thiol Reactive Linkers are used in ADC conjugation to target thiol group on biomolecules. Maleimide, acrylamide, vinyl sulfone, bromide and tosylated linkers are some of the most useful thiol reactive agents for bioconjugation. The maleimide linkers allow selective labeling of sulfhydryl groups such as cysteine residues in proteins and pepties, and oligonucleotides. Functionalized maleimide linkers with PEG spacer of different length offers researchers flexibility to fine tune their conjugation applications.

Besides amine-reactive compounds, thiol or sulfhydryls (–SH) reactive linkers are the most common crosslinkers for protein and other bioconjugations. Thiols exist in proteins’ side-chain of cysteine (Cys, C) amino acids. They often exist as disulfide bonds (–S–S–) within or between polypeptide chains as the basis of native tertiary or quaternary protein structure. Only the free or reduced sulfhydryl groups (–SH) are available for reaction with thiol-reactive compounds.

Thiol reactive Linkers
  • Bromo PEG
  • Cleavable PEG
  • PEG Maleimide
  • PEG Tosylate
Catalog# Name Structure M.W. Purity Pricing
Top selling High purity Thiol reactive Linkers
AP11893Tos-PEG13-Tos855.02≥95% Pricing
AP12084t-Boc-Aminooxy-PEG4-Tos463.54≥95% Pricing
AP11876Tos-PEG6-t-Butyl ester520.63≥95% Pricing
AP11210PEG4-Tos304.36≥95% Pricing
AP11380m-PEG11-Tos626.76≥95% Pricing
AP11887Tos-PEG5-Tos502.59≥95% Pricing
AP11884Tos-PEG7-CH2CO2tBu550.66≥95% Pricing
AP11212PEG6-Tos392.46≥95% Pricing
AP11879Tos-PEG13-t-butyl ester829.01≥95% Pricing
AP11898Tos-PEG4-CH2CO2H362.39≥95% Pricing

PEG Applications

ADC Conjugation
Click Chemistry
Dye Labeling
Drug Delivery

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