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DOTA PEG linkers combine a DOTA chelator with a PEG chain. DOTA binds metal ions like copper, gallium, or lutetium. PEG increases stability and solubility.

In imaging and therapy, these linkers attach to targeting molecules for precise delivery. They also enable radiolabeling for non-invasive imaging.

DOTA PEG linkers improve drug half-life and reduce immunogenicity. They are essential in cancer, neurological, and inflammatory treatments, enhancing both drug delivery and diagnostics.

DOTA Reagent DOTA PEG

Cat# Name Structure M.W. Purity Pricing
Bromoacetamido-PEG-DOTA
AP12027Bromoacetamido-PEG5-DOTA
Quick viewBromoacetamido-PEG5-DOTA
787.7≥95% Pricing
DOTA-(t-Butyl)3-PEG-azide
AP11518DOTA-(t-Butyl)3-PEG5-azide
Quick viewDOTA-(t-Butyl)3-PEG5-azide
861.09≥95% Pricing
DOTA-NHS ESTER
AP13088DOTA-NHS ESTER
Quick viewDOTA-NHS ESTER
501.49≥95% Pricing
DOTA-PEG-amine
AP12200DOTA-PEG5-amine HCl salt
Quick viewDOTA-PEG5-amine HCl salt
666.77≥95% Pricing
DOTA-PEG-azide
AP11517DOTA-PEG5-azide
Quick viewDOTA-PEG5-azide
692.77≥95% Pricing
AP15411DOTA-PEG4-azide hydrochloride
Quick viewDOTA-PEG4-azide hydrochloride
750.51≥NMR 1H and HPLC-MS (95+%) Pricing
DOTA-PEG-DBCO
AP11147DOTA-PEG5-C6-DBCO
Quick viewDOTA-PEG5-C6-DBCO
982.14≥95% Pricing
FA-PEG-DOTA
AP13089FA-PEG3-DOTA
Quick viewFA-PEG3-DOTA
1002.05≥95% Pricing
AP13135DOTA-PEG(24)-TFP*2TFA
Quick viewDOTA-PEG(24)-TFP*2TFA
1680.81*228.05≥95% Pricing
Other DOTA PEG
AP15418DOTAGA-tetra (t-Bu ester)
Quick viewDOTAGA-tetra (t-Bu ester)
700.9≥94% Pricing
AP15437NO2A-Butyne
Quick viewNO2A-Butyne
354.4≥94% Pricing
AP15420p-NO₂-Bn-Cyclen
Quick viewp-NO₂-Bn-Cyclen
307.4≥94% Pricing
AP15422DOTAM-mono-acid
Quick viewDOTAM-mono-acid
401.5≥95% Pricing
AP15438NO2A-Azide
Quick viewNO2A-Azide
494.8≥94% Pricing
AP15309DOTA(OtBu)3
Quick viewDOTA(OtBu)3
572.73≥95% Pricing
AP13134DOTA-PNP
Quick viewDOTA-PNP
525.51≥95% Pricing
AP15435Maleimido-mono-amide-NOTA
Quick viewMaleimido-mono-amide-NOTA
539.5≥94% Pricing
AP15439p-NH₂-Bn-PCTA
Quick viewp-NH₂-Bn-PCTA
594.5≥94% Pricing
AP15436DTPA-tetra (t-Bu ester)
Quick viewDTPA-tetra (t-Bu ester)
617.8≥94% Pricing
AP15426p-NH₂-Bn-DOTA
Quick viewp-NH₂-Bn-DOTA
655.4≥94% Pricing
AP15434Butyne-DOTA
Quick viewButyne-DOTA
683.6≥94% Pricing
AP15424p-NO2-Bn-DOTA
Quick viewp-NO2-Bn-DOTA
685.4≥94% Pricing
AP15432p-SCN-Bn-DOTA
Quick viewp-SCN-Bn-DOTA
687.8≥94% Pricing
AP15433DO3A-Thiol
Quick viewDO3A-Thiol
691.6≥94% Pricing
AP154252-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester)
Quick view2-Aminoethyl-mono-amide-DOTA-tris(t-Bu ester)
695.7≥94% Pricing
AP15427Azido-mono-amide-DOTA-tris(t-Bu ester)
Quick viewAzido-mono-amide-DOTA-tris(t-Bu ester)
735.8≥94% Pricing
AP15440p-SCN-Bn-Deferoxamine
Quick viewp-SCN-Bn-Deferoxamine
752.9≥94% Pricing
AP15423Butyne-DOTA-tris(t-butyl ester)
Quick viewButyne-DOTA-tris(t-butyl ester)
769.8≥94% Pricing
AP15419Maleimido-mono-amide-DOTA
Quick viewMaleimido-mono-amide-DOTA
786.5≥94% Pricing
AP154314-Aminobutyl-DOTA-tris (t-butyl ester)
Quick view4-Aminobutyl-DOTA-tris (t-butyl ester)
788.8≥94% Pricing
AP15430DOTA-mono-NHS tris (t-Bu ester)
Quick viewDOTA-mono-NHS tris (t-Bu ester)
815.8≥94% Pricing
AP15429Maleimido-mono-amide-DOTA-tris (t-Bu ester)
Quick viewMaleimido-mono-amide-DOTA-tris (t-Bu ester)
840.8≥94% Pricing
AP15428p-NH₂-Bn-DOTA-tetra(t-Bu ester)
Quick viewp-NH₂-Bn-DOTA-tetra(t-Bu ester)
848≥94% Pricing
AP15421Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
Quick viewFmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)
1069.1≥94% Pricing

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    DOTA PEG Linkers: Enhancing Targeted Imaging and Therapy Overview: DOTA PEG linkers are essential tools in pharmaceutical research, combining a DOTA chelator with a polyethylene glycol (PEG) chain. The DOTA moiety binds to metal ions like copper, gallium, or lutetium, while PEG enhances stability and solubility. Applications:
    • Targeted Molecular Imaging and Therapy: Conjugating DOTA PEG linkers to targeting molecules (e.g., antibodies or ligands) enables selective delivery of therapeutic agents. The DOTA chelator can also label the conjugate with radioactive isotopes for non-invasive imaging.
    • Novel Therapeutics: Used in developing treatments for cancer, neurological disorders, and inflammatory diseases, DOTA PEG linkers improve pharmacokinetics by extending drug half-life and reducing immunogenicity.
    Benefits:
    • Increased Stability and Solubility: PEG enhances the properties of the conjugate.
    • Enhanced Targeting: Enables precise delivery and imaging of specific cells or tissues.
    In summary, DOTA PEG linkers play a crucial role in advancing targeted therapies and imaging techniques, offering improved drug delivery and diagnostic capabilities. ref: Parry JJ, Kelly TS, Andrews R, Rogers BE. In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties. Bioconjug Chem. 2007 Jul-Aug;18(4):1110-7. doi: 10.1021/bc0603788. Epub 2007 May 16. PMID: 17503761.