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DOTA PEG linkers combine a DOTA chelator with a PEG chain. DOTA binds metal ions like copper, gallium, or lutetium. PEG increases stability and solubility.

In imaging and therapy, these linkers attach to targeting molecules for precise delivery. They also enable radiolabeling for non-invasive imaging.

DOTA PEG linkers improve drug half-life and reduce immunogenicity. They are essential in cancer, neurological, and inflammatory treatments, enhancing both drug delivery and diagnostics.

DOTA PEG

Cat# Name Structure M.W. Purity Pricing
Bromoacetamido-PEG-DOTA
AP12027Bromoacetamido-PEG5-DOTA
Quick viewBromoacetamido-PEG5-DOTA
787.7≥95% Pricing
DOTA-(t-Butyl)3-PEG-azide
AP11518DOTA-(t-Butyl)3-PEG5-azide
Quick viewDOTA-(t-Butyl)3-PEG5-azide
861.09≥95% Pricing
DOTA-NHS ESTER
AP13088DOTA-NHS ESTER
Quick viewDOTA-NHS ESTER
501.49≥95% Pricing
DOTA-PEG-amine
AP12200DOTA-PEG5-amine HCl salt
Quick viewDOTA-PEG5-amine HCl salt
666.77≥95% Pricing
DOTA-PEG-azide
AP11517DOTA-PEG5-azide
Quick viewDOTA-PEG5-azide
692.77≥95% Pricing
DOTA-PEG-DBCO
AP11147DOTA-PEG5-C6-DBCO
Quick viewDOTA-PEG5-C6-DBCO
982.14≥95% Pricing
FA-PEG-DOTA
AP13089FA-PEG3-DOTA
Quick viewFA-PEG3-DOTA
1002.05≥95% Pricing
AP13135DOTA-PEG(24)-TFP*2TFA
Quick viewDOTA-PEG(24)-TFP*2TFA
1680.81*228.05≥95% Pricing
Other DOTA PEG
AP15309DOTA(OtBu)3
Quick viewDOTA(OtBu)3
572.73≥95% Pricing
AP13134DOTA-PNP
Quick viewDOTA-PNP
525.51≥95% Pricing

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    DOTA PEG Linkers: Enhancing Targeted Imaging and Therapy Overview: DOTA PEG linkers are essential tools in pharmaceutical research, combining a DOTA chelator with a polyethylene glycol (PEG) chain. The DOTA moiety binds to metal ions like copper, gallium, or lutetium, while PEG enhances stability and solubility. Applications:
    • Targeted Molecular Imaging and Therapy: Conjugating DOTA PEG linkers to targeting molecules (e.g., antibodies or ligands) enables selective delivery of therapeutic agents. The DOTA chelator can also label the conjugate with radioactive isotopes for non-invasive imaging.
    • Novel Therapeutics: Used in developing treatments for cancer, neurological disorders, and inflammatory diseases, DOTA PEG linkers improve pharmacokinetics by extending drug half-life and reducing immunogenicity.
    Benefits:
    • Increased Stability and Solubility: PEG enhances the properties of the conjugate.
    • Enhanced Targeting: Enables precise delivery and imaging of specific cells or tissues.
    In summary, DOTA PEG linkers play a crucial role in advancing targeted therapies and imaging techniques, offering improved drug delivery and diagnostic capabilities. ref: Parry JJ, Kelly TS, Andrews R, Rogers BE. In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties. Bioconjug Chem. 2007 Jul-Aug;18(4):1110-7. doi: 10.1021/bc0603788. Epub 2007 May 16. PMID: 17503761.