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The maleimide linkers react specifically with sulfhydryl groups when the pH is between 6.5 and 7.5. The reaction forms a stable thioether linkage. When pH is higher than 8.5, the maleimide linkers readily react with primary amines. Maleimides do not react with tyrosines, histidines or methionines.

AxisPharm provide a broad range of maleimide linkers with various functional groups, such as Mal-PEG-azide, Mal-PEG-alkyne, Mal-PEG-NHS ester, Mal-PEG-TCO, Mal-PEG-BCN, Mal-PEG-DBCO and Mal-PEG-fluorescent dye probes, Mal-PEG-folate and Mal-PEG-biotin, etc.

Catalog# Name Structure M.W. Purity Pricing
Maleimide Linkers
AP114891-(2-Aminoethyl)-1H-pyrrole-2,5-dione TFA salt140.14≥95% Buy
AP114993,4-Dibromo-Mal-PEG2-Amine TFA salt386.04≥95% Buy
AP115003,4-Dibromo-Mal-PEG4-t-butyl ester559.25≥95% Buy
AP114983,4-Dibromo-Mal-PEG8-acid679.35≥95% Buy
AP115013,4-Dibromo-Mal-PEG8-t-butyl ester735.46≥95% Buy
AP114884-((2,5-Dioxo-2H-pyrrol-1(5H)-yl)methyl)cyclohexanecarboxylic acid237.26≥95% Buy
AP114875-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid197.19≥95% Buy
AP119485-Maleimido-pentanoic NHS ester294.26≥95% Buy
AP114916-Maleimidocaproic acid PFP ester377.27≥95% Buy
AP11561Azido-PEG3-Maleimide369.38≥95% Buy
AP11041Biotin-PEG11-Mal922.1≥95% Buy
AP11496Bis-Mal-Lysine-PEG4-acid695.72≥95% Buy
AP11497Bis-Mal-Lysine-PEG4-TFP ester843.78≥95% Buy
AP11494Bis-Mal-PEG11846.93≥95% Buy
AP11495Bis-Mal-PEG191199.35≥95% Buy
AP11492Bis-Mal-PEG3494.5≥95% Buy
AP11493Bis-Mal-PEG6626.66≥95% Buy
AP11515Di(N-succinimidyl)adipate340.29≥95% Buy
AP10163DSPE-PEG8-Mal1251.62≥95% Buy
AP11417Lipoamide-PEG11-Mal884.11≥95% Buy
AP11416Lipoamide-PEG3-Mal559.74≥95% Buy
AP11363m-PEG12-Mal710.82≥95% Buy
AP11364m-PEG24-Mal1239.45≥95% Buy
AP11365m-PEG36-Mal1768.09≥95% Buy
AP11362m-PEG4-Mal358.39≥95% Buy
AP11366m-PEG48-Mal2296.72≥95% Buy
AP11476Mal-amido-PEG10-acid680.75≥95% Buy
AP11477Mal-amido-PEG12-acid768.85≥95% Buy
AP11485Mal-amido-PEG12-TFP ester916.91≥95% Buy
AP11480Mal-amido-PEG2-NHS425.39≥95% Buy
AP11482Mal-amido-PEG2-TFP ester476.38≥95% Buy
AP11192Mal-amido-PEG2-Val-Cit-PAB-OH689.77≥95% Buy
AP11193Mal-amido-PEG2-Val-Cit-PAB-PNP854.87≥95% Buy
AP11478Mal-amido-PEG24-acid1297.49≥95% Buy
AP11486Mal-amido-PEG24-TFP ester1445.55≥95% Buy
AP11466Mal-Amido-PEG4-t-butyl ester472.54≥95% Buy
AP11483Mal-amido-PEG4-TFP ester564.49≥95% Buy
AP11475Mal-amido-PEG6-acid504.53≥95% Buy
AP11481Mal-amido-PEG6-NHS601.61≥95% Buy
AP11484Mal-amido-PEG8-TFP ester740.7≥95% Buy
AP11924Mal-amido-PEG8-val-gly-PAB-OH853.96≥95% Buy
AP11479Mal-amido-PEG9-amine TFA salt607.7≥95% Buy
AP11474Mal-amido-PEG9-NHBoc707.82≥95% Buy
AP11175Mal-NH-ethyl-SS-propionic acid332.39≥95% Buy
AP11444Mal-PEG1-acid213.19≥95% Buy
AP11490Mal-PEG1-Bromide248.08≥95% Buy
AP11448Mal-PEG1-NHS ester310.26≥95% Buy
AP11455Mal-PEG1-PFP379.24≥95% Buy
AP11461Mal-PEG1-t-butyl ester269.3≥95% Buy
AP11447Mal-PEG12-acid697.77≥95% Buy
AP11471Mal-PEG12-alcohol625.71≥95% Buy
AP11454Mal-PEG12-NHS ester794.85≥95% Buy
AP11465Mal-PEG12-t-butyl ester753.88≥95% Buy
AP11467Mal-PEG2-alcohol185.18≥95% Buy
AP11472Mal-PEG2-amine TFA salt228.25≥95% Buy
AP11473Mal-PEG2-NH-Boc328.37≥95% Buy
AP11449Mal-PEG2-NHS ester354.32≥95% Buy
AP11456Mal-PEG2-PFP423.29≥95% Buy
AP11445Mal-PEG3-acid301.3≥95% Buy
AP11468Mal-PEG3-alcohol229.23≥95% Buy
AP11450Mal-PEG3-NHS ester398.37≥95% Buy
AP11457Mal-PEG3-PFP467.35≥95% Buy
AP11462Mal-PEG3-t-butyl ester357.4≥95% Buy
AP11469Mal-PEG4-alcohol273.29≥95% Buy
AP11458Mal-PEG4-PFP511.4≥95% Buy
AP11191Mal-PEG4-Val-Cit-PAB-PNP871.9≥95% Buy
AP11446Mal-PEG5-acid389.4≥95% Buy
AP11451Mal-PEG5-NHS ester486.47≥95% Buy
AP11459Mal-PEG5-PFP555.45≥95% Buy
AP11463Mal-PEG5-t-butyl ester445.51≥95% Buy
AP11452Mal-PEG6-NHS ester530.53≥95% Buy
AP11460Mal-PEG6-PFP599.5≥95% Buy
AP11470Mal-PEG8-alcohol449.5≥95% Buy
AP11453Mal-PEG8-NHS ester618.63≥95% Buy
AP11464Mal-PEG8-t-butyl ester577.67≥95% Buy
AP12209N-(Mal-PEG6)-N-bis(PEG3-amine) TFA salt854.01≥95% Buy
AP11757N-(Mal-PEG6)-N-bis(PEG7-TCO)1652.97≥95% Buy
AP11743N-Mal-N-bis(PEG2-acid)488.49≥95% Buy
AP11754N-Mal-N-bis(PEG2-amine) TFA salt430.5≥95% Buy
AP11758N-Mal-N-bis(PEG2-NH-Boc)630.74≥95% Buy
AP11747N-Mal-N-bis(PEG2-NHS ester)682.64≥95% Buy
AP11760N-Mal-N-bis(PEG2-t-butyl ester)600.71≥95% Buy
AP11744N-Mal-N-bis(PEG4-acid)664.7≥95% Buy
AP11755N-Mal-N-bis(PEG4-amine) TFA salt606.71≥95% Buy
AP11759N-Mal-N-bis(PEG4-NH-Boc)806.95≥95% Buy
AP11748N-Mal-N-bis(PEG4-NHS ester)858.85≥95% Buy
AP11188PC Mal-NHS carbonate ester562.49≥95% Buy
AP11949SMPH Crosslinker379.37≥95% Buy
AP11629tert-butyl 2-(2,5-dioxo-2H-pyrrol-1(5H)-yl)ethylcarbamate240.26≥95% Buy
AP116306-Mal-C6-Boc-Amine296.37≥95% Buy
AP11756Tri(Mal-PEG2-amide)-amine1077.16≥95% Buy
AP10932Mal-propionylamido-PEG2-NHS acetate411.37≥95% Buy
AP10595Boc-HyNic-PEG1-Mal419.44≥95% Buy
AP10801TCO-PEG1-amido maleimide407.46≥95% Buy
AP10802TCO-PEG2-amido maleimide451.51≥95% Buy
AP10803TCO-PEG3-amido maleimide495.57≥95% Buy
AP10804TCO-PEG4-amido maleimide539.62≥95% Buy
AP10805TCO-PEG5-amido maleimide583.67≥95% Buy
AP10806TCO-PEG6-amido maleimide627.72≥95% Buy
AP10807TCO-PEG7-amido maleimide671.78≥95% Buy