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The maleimide linkers react specifically with sulfhydryl groups when the pH is between 6.5 and 7.5. The reaction forms a stable thioether linkage. When pH is higher than 8.5, the maleimide linkers readily react with primary amines. Maleimides do not react with tyrosines, histidines or methionines.

AxisPharm provide a broad range of maleimide linkers with various functional groups, such as Mal-PEG-azide, Mal-PEG-alkyne, Mal-PEG-NHS ester, Mal-PEG-TCO, Mal-PEG-BCN, Mal-PEG-DBCO and Mal-PEG-fluorescent dye probes, Mal-PEG-folate and Mal-PEG-biotin, etc.

Catalog# Name Structure M.W. Purity Pricing
Maleimide Linkers
AP10595Boc-HyNic-PEG1-Mal419.44≥95% Pricing
AP10062Mal-amide-PEG2-oxyamine315.32≥95% Pricing
AP10061Mal-amide-PEG3-oxyamine359.37≥95% Pricing
AP10059Mal-amide-PEG3-oxyamineBoc459.49≥95% Pricing
AP10628APDye 488 Maleimide684.65≥95% Pricing
AP10739BCN-endo-PEG3-Maleimide519.6≥95% Pricing
AP10738BCN-exo-PEG7-Maleimide739.86≥95% Pricing
AP10593HyNic-PEG1-Mal359.39≥95% Pricing
AP11175Mal-NH-ethyl-SS-propionic acid332.39≥95% Pricing
AP11188PC Mal-NHS carbonate ester562.49≥95% Pricing
AP10860DBCO-maleimide356.38≥95% Pricing
AP10300DBCO-Mal427.45≥95% Pricing
AP10855DBCO-Sulfo-Maleimide578.6≥95% Pricing
AP10313DBCO-NH-PEG2-Mal586.64≥95% Pricing
AP10858DBCO-amido-PEG4-amido-Maleimide674.75≥95% Pricing
AP10315DBCO-NH-PEG6-Mal762.85≥95% Pricing
AP10856DBCO-Sulfo-PEG4-Maleimide825.89≥95% Pricing
AP10316DBCO-NH-PEG12-Mal1027.16≥95% Pricing
AP10158m-PEG2-Mal199.21≥95% Pricing
AP11362m-PEG4-Mal358.39≥95% Pricing
AP10186m-PEG6-NH-Mal446.49≥95% Pricing
AP10187m-PEG8-NH-Mal534.6≥95% Pricing
AP11363m-PEG12-Mal710.82≥95% Pricing
AP11364m-PEG24-Mal1239.45≥95% Pricing
AP11365m-PEG36-Mal1768.09≥95% Pricing

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