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The maleimide linkers react specifically with sulfhydryl groups when the pH is between 6.5 and 7.5. The reaction forms a stable thioether linkage. When pH is higher than 8.5, the maleimide linkers readily react with primary amines. Maleimides do not react with tyrosines, histidines or methionines.

AxisPharm provide a broad range of maleimide linkers with various functional groups, such as Mal-PEG-azide, Mal-PEG-alkyne, Mal-PEG-NHS ester, Mal-PEG-TCO, Mal-PEG-BCN, Mal-PEG-DBCO and Mal-PEG-fluorescent dye probes, Mal-PEG-folate and Mal-PEG-biotin, etc.

Catalog# Name Structure M.W. Purity Pricing
Maleimide Linkers
AP10595Boc-HyNic-PEG1-Mal419.44≥95% Pricing
AP10062Mal-amide-PEG2-oxyamine315.32≥95% Pricing
AP10061Mal-amide-PEG3-oxyamine359.37≥95% Pricing
AP10059Mal-amide-PEG3-oxyamineBoc459.49≥95% Pricing
AP10045Mal-CH2CyclohexylcarboxylhydrazideTFA348.30≥95% Pricing
AP10859DBCO-amido-PEG4-Maleimide603.67≥95% Pricing
AP108672,5-dioxopyrrolidin-1-yl 4-methyl-4-(pyridin-2-yldisulfaneyl)pentanoate354.44≥95% Pricing
AP106526-Maleimido-1-Hexanal195.22≥95% Pricing
AP10628AFDye 488 Maleimide684.65≥95% Pricing
AP10680APN-Maleimide222.2≥95% Pricing
AP10577BibromoMal-PEG1 Folate766.35≥95% Pricing
AP10739BCN-endo-PEG3-Maleimide519.6≥95% Pricing
AP106461-(2-hydroxyethyl)-1H-pyrrole-2,5-dione141.13≥95% Pricing
AP106561-(3-hydroxypropyl)-1H-pyrrole-2,5-dione155.15≥95% Pricing
AP10738BCN-exo-PEG7-Maleimide739.86≥95% Pricing
AP106471-(3-isocyanatopropyl)-1H-pyrrole-2,5-dione180.16≥95% Pricing
AP106551,4-Bis-maleimidobutane248.24≥95% Pricing
AP106533-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl chloride187.58≥95% Pricing
AP10593HyNic-PEG1-Mal359.39≥95% Pricing
AP10547Mal-(CH2)10-COOH281.35≥95% Pricing
AP10550Mal-(CH2)10-COONHS378.42≥95% Pricing
AP10654Mal-hexyoxyamine248.71≥95% Pricing
AP10138Mal-NH-PEG2-BCN475.54≥95% Pricing
AP10576Mal-PEG1 Folate608.56≥95% Pricing
AP10591Mal-PEG2-BocNH Tyrosine Methyl Ester462.5≥95% Pricing