Mal-PEG-azide

Mal-PEG-azide is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains an azide functional group (-N3) attached to the end of a PEG chain, with a maleimide group (-Mal) attached to the other end.

Mal-PEG-azide has been extensively utilized in the development of novel drug conjugates, such as antibody-drug conjugates (ADCs) and protein-peptide conjugates. Its unique chemical properties allow for the site-specific conjugation of therapeutic agents, such as drugs, proteins, and peptides, to the PEG chain via click chemistry reactions. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.

In addition to its use in drug conjugates, Mal-PEG-azide has also been employed as a crosslinker in various biomedical applications. For example, it can be used to crosslink biomolecules, such as proteins and nucleic acids, to form hydrogels or other 3D structures.